1 to 4 of 4 literature results

• The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

  The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interl…

  Authors: Luigi Franchi, Tatjana Eigenbrod, Raúl Muñoz-Planillo, Gabriel Nuñez

  Source: Nature immunology. 2009 Mar

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• A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.

  The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood. In this study, we show that the ability of Staphylo…

  Authors: Raúl Muñoz-Planillo, Luigi Franchi, Lloyd S Miller, Gabriel Núñez

  Source: Journal of immunology (Baltimore, Md. : 1950). 2009 Sep 15

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• Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.

  Macrophages play a crucial role in the innate immune response against the human pathogen Streptococcus pyogenes, yet the innate immune response agains…

  Authors: Jürgen Harder, Luigi Franchi, Raúl Muñoz-Planillo, Jong-Hwan Park, Thornik Reimer, Gabriel Núñez

  Source: Journal of immunology (Baltimore, Md. : 1950). 2009 Nov 1

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• The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.

  Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agen…

  Authors: Mohamed Lamkanfi, Amal Amer, Thirumala-Devi Kanneganti, Raúl Muñoz-Planillo, Grace Chen, Peter Vandenabeele, Anne Fortier, Philippe Gros, Gabriel Núñez

  Source: Journal of immunology (Baltimore, Md. : 1950). 2007 Jun 15

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