1 to 10 of 61 literature results

• Metabolic stability: main enzymes involved and best tools to assess it.

  The introduction of in vitro tools to predict clearance in the early discovery process has led to new ways of working. Combined with metabolite identi…

  Authors: Romuald Laine

  Source: Current drug metabolism. 2008 Nov

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• Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate.

  Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mec…

  Authors: D J Vocadlo, G J Davies, R Laine, S G Withers

  Source: Nature. 2001 Aug 23

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• Three-dimensional imaging of Förster resonance energy transfer in heterogeneous turbid media by tomographic fluorescent lifetime imaging.

  We report a three-dimensional time-resolved tomographic imaging technique for localizing protein-protein interaction and protein conformational change…

  Authors: James McGinty, Vadim Y Soloviev, Khadija B Tahir, Romain Laine, Daniel W Stuckey, Joseph V Hajnal, Alessandro Sardini, Paul M W French, Simon R Arridge

  Source: Optics letters. 2009 Sep 15

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• Performance of bifidobacteria in oat-based media.

  Thirteen Bifidobacterium strains were isolated form the faeces of healthy elderly subjects. The ability of the isolated strains to acidify and survive…

  Authors: Riikka Laine, Seppo Salminen, Yoshimi Benno, Arthur C Ouwehand

  Source: International journal of food microbiology. 2003 May 25

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• Fluorescence lifetime optical projection tomography.

  We describe a quantitative fluorescence projection tomography technique which measures the 3-D fluorescence lifetime distribution in optically cleared…

  Authors: James McGinty, Khadija B Tahir, Romain Laine, Clifford B Talbot, Christopher Dunsby, Mark A A Neil, Laura Quintana, James Swoger, James Sharpe, Paul M W French

  Source: Journal of biophotonics. 2008 Oct

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• Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO).

  Tresperimus (Cellimis), a new immunosuppressive agent, is mainly eliminated in the rat through metabolism, in which the oxidative deamination of the p…

  Authors: P Claud, Y Artur, J P Guichard, R Laine

  Source: Fundamental & clinical pharmacology. 2002 Dec

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• A serious threat to the medical chief residency.

  Authors: R S Crausman, R Lain

  Source: Annals of internal medicine. 1997 Aug 1

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• Forensic dental and medical response to the Bali bombing. A personal perspective.

  After the Bali bombing on 12 October 2002, once the survivors had been treated or evacuated, many dead, severely burned and fragmented bodies were lef…

  Authors: Russell Lain, Chris Griffiths, John M N Hilton

  Source: The Medical journal of Australia. 2003 Oct 6

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• In vitro metabolism of tresperimus by human vascular semicarbazide-sensitive amine oxidase.

  Tresperimus (Cellimis), a new immunosuppressive agent is mainly eliminated through an extensive nonhepatic metabolism, in which the oxidative deaminat…

  Authors: Philippe Claud, Yves Artur, Romuald Laine

  Source: Drug metabolism and disposition: the biological fate of chemicals. 2002 Jun

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• Intraductal foreign body in the breast found on sonography.

  Authors: Heikki R Laine, Henri Kurunmäki, Aarne I Koskimies

  Source: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2008 Sep

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