1 to 6 of 6 literature results

• Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.

  TOPORS is the first example of a protein that possesses both ubiquitin and SUMO E3 ligase activity. The ubiquitination activity maps to a conserved RI…

  Authors: Hye-Jin Park, Haiyan Zheng, Diptee Kulkarni, John Kerrigan, Pooja Pungaliya, Ahamed Saleem, Eric H Rubin

  Source: Biochemistry. 2008 Dec 30

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• TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

  TOPORS is the first example of a protein with both ubiquitin and SUMO-1 E3 ligase activity and has been implicated as a tumor suppressor in several di…

  Authors: Pooja Pungaliya, Diptee Kulkarni, Hye-Jin Park, Henderson Marshall, Haiyan Zheng, Henry Lackland, Ahamed Saleem, Eric H Rubin

  Source: Journal of proteome research. 2007 Oct

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• Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.

  Clinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but may involve increased expre…

  Authors: Murugesan K Gounder, Ahamed S Nazar, Ahamed Saleem, Pooja Pungaliya, Diptee Kulkarni, Richard Versace, Eric H Rubin

  Source: Investigational new drugs. 2008 Jun

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• Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

  The NKX3.1 gene located at 8p21.2 encodes a homeodomain-containing transcription factor that acts as a haploinsufficient tumor suppressor in prostate …

  Authors: Bin Guan, Pooja Pungaliya, Xiang Li, Carlos Uquillas, Laura N Mutton, Eric H Rubin, Charles J Bieberich

  Source: The Journal of biological chemistry. 2008 Feb 22

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• Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

  Mutations in leucine-rich repeat kinase 2 (LRRK2) comprise the leading cause of autosomal dominant Parkinson's disease, with age of onset and symptoms…

  Authors: Vasanti S Anand, Laurie J Reichling, Kerri Lipinski, Wayne Stochaj, Weili Duan, Kerry Kelleher, Pooja Pungaliya, Eugene L Brown, Peter H Reinhart, Richard Somberg,…

  Source: The FEBS journal. 2009 Jan

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• Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

  The human topoisomerase I- and p53-binding protein topors contains a highly conserved, N-terminal C3HC4-type RING domain that is homologous to the RIN…

  Authors: Rajeev Rajendra, Diptee Malegaonkar, Pooja Pungaliya, Henderson Marshall, Zeshaan Rasheed, James Brownell, Leroy F Liu, Stuart Lutzker, Ahamed Saleem, Eric H Rubin

  Source: The Journal of biological chemistry. 2004 Aug 27

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