1 to 10 of 52 literature results

• Germline mutation of INI1/SMARCB1 in familial schwannomatosis.

  Patients with schwannomatosis develop multiple schwannomas but no vestibular schwannomas diagnostic of neurofibromatosis type 2. We report an inactiva…

  Authors: Theo J M Hulsebos, Astrid S Plomp, Ruud A Wolterman, Els C Robanus-Maandag, Frank Baas, Pieter Wesseling

  Source: American journal of human genetics. 2007 Apr

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• Fatal consequences of an ear infection.

  Authors: Xenia L Stalpers, Mijke Smink-Bol, Paul E Verweij, Pieter Wesseling, Gert W van Dijk

  Source: Lancet. 2009 May 9

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• Aminopeptidase A is a functional target in angiogenic blood vessels.

  We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain…

  Authors: Serena Marchiò, Johanna Lahdenranta, Reinier O Schlingemann, Donatella Valdembri, Pieter Wesseling, Marco A Arap, Amin Hajitou, Michael G Ozawa, Martin Trepel, Ricardo J Giordano,…

  Source: Cancer cell. 2004 Feb

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• Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

  Glioblastomas are highly aggressive primary brain tumors. Curative treatment by surgery and radiotherapy is generally impossible due to the presence o…

  Authors: An Claes, Pieter Wesseling, Judith Jeuken, Cathy Maass, Arend Heerschap, William P J Leenders

  Source: Molecular cancer therapeutics. 2008 Jan

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• Diffuse glioma growth: a guerilla war.

  In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the neuropil. This growth pattern is a major factor in therape…

  Authors: An Claes, Albert J Idema, Pieter Wesseling

  Source: Acta neuropathologica. 2007 Nov

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• Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

  The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analys…

  Authors: Joannes F M Jacobs, Albert J Idema, Kalijn F Bol, Stefan Nierkens, Oliver M Grauer, Pieter Wesseling, J André Grotenhuis, Peter M Hoogerbrugge, I Jolanda M de Vries, Gosse J Adema

  Source: Neuro-oncology. 2009 Aug

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• RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations.

  Aberrant RAS/RAF signaling has been reported to be important for many tumor types including gliomas. Activation of the RAS/RAF pathway can result from…

  Authors: Judith Jeuken, Caroline van den Broecke, Sabine Gijsen, Sandra Boots-Sprenger, Pieter Wesseling

  Source: Acta neuropathologica. 2007 Aug

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• Differential effects of vascular endothelial growth factor A isoforms in a mouse brain metastasis model of human melanoma.

  We reported previously that vascular endothelial growth factor isoform A (VEGF-A) expression by Mel57 human melanoma cells led to tumor progression in…

  Authors: Benno Küsters, Robert M W de Waal, Pieter Wesseling, Kiek Verrijp, Cathy Maass, Arend Heerschap, Jelle O Barentsz, Fred Sweep, Dirk J Ruiter, William P J Leenders

  Source: Cancer research. 2003 Sep 1

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• Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.

  Background. Recent studies have shown that the clinical outcome of anaplastic oligodendroglial tumors is variable, but also that the histological diag…

  Authors: Mathilde C M Kouwenhoven, Thierry Gorlia, Johan M Kros, Ahmed Ibdaih, Alba A Brandes, Jacolien E C Bromberg, Karima Mokhtari, Sjoerd G van Duinen, Johannes L Teepen, Pieter Wesseling,…

  Source: Neuro-oncology. 2009 Feb 17

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• Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis.

  We investigated the mechanisms of vascularization in a brain metastases model of malignant melanoma. Parenchymal metastases expressing little vascular…

  Authors: Benno Küsters, William P J Leenders, Pieter Wesseling, Debby Smits, Kiek Verrijp, Dirk J Ruiter, Johannes P W Peters, Albert J van Der Kogel, Robert M W de Waal

  Source: Cancer research. 2002 Jan 15

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