1 to 10 of 28 literature results

• Human T cell responses against melanoma.

  Many antigens recognized by autologous T lymphocytes have been identified on human melanoma. Melanoma patients usually mount a spontaneous T cell resp…

  Authors: Thierry Boon, Pierre G Coulie, Benoît J Van den Eynde, Pierre van der Bruggen

  Source: Annual review of immunology. 2006

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• Human tumor-specific T lymphocytes: does function matter more than number?

  In recent years, several clinical trials have involved the vaccination of cancer patients with tumor-specific antigens that are recognized by T lympho…

  Authors: Pierre G Coulie, Thierry Connerotte

  Source: Current opinion in immunology. 2005 Jun

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• Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients.

  Dendritic cell (DC) targeting in vivo has recently been shown to confer strong and protective cytotoxic T lymphocyte (CTL)-based immunity in tumor mur…

  Authors: Raffaella Fontana, Marco Bregni, Arcadi Cipponi, Laura Raccosta, Cristina Rainelli, Daniela Maggioni, Francesca Lunghi, Fabio Ciceri, Sylvain Mukenge, Claudio Doglioni,…

  Source: Blood. 2009 Feb 19

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• Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human treg.

  Human regulatory T cell (Treg) and T helper (Th) clones secrete the latent form of transforming growth factor beta (TGF-beta), in which the mature TGF…

  Authors: Julie Stockis, Didier Colau, Pierre G Coulie, Sophie Lucas

  Source: European journal of immunology. 2009 Sep 11

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• Functions of Anti-MAGE T-cells induced in melanoma patients under different vaccination modalities.

  Tumor regressions have been observed in a small proportion of melanoma patients vaccinated with a MAGE-A3 peptide presented by HLA-A1, administered as…

  Authors: Thierry Connerotte, Aline Van Pel, Danièle Godelaine, Eric Tartour, Beatrice Schuler-Thurner, Sophie Lucas, Kris Thielemans, Gerold Schuler, Pierre G Coulie

  Source: Cancer research. 2008 May 15

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• T-cell responses of vaccinated cancer patients.

  Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Sev…

  Authors: Pierre G Coulie, Pierre van der Bruggen

  Source: Current opinion in immunology. 2003 Apr

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• Comparison of stable human Treg and Th clones by transcriptional profiling.

  From cancerous and non-cancerous patients, we derived stable clones of CD4(+) Treg, defined as clones that expressed high CD25 at rest, were anergic i…

  Authors: Julie Stockis, Wolfram Fink, Violaine François, Thierry Connerotte, Charles de Smet, Laurent Knoops, Pierre van der Bruggen, Thierry Boon, Pierre G Coulie, Sophie Lucas

  Source: European journal of immunology. 2009 Mar

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• A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes.

  We have identified a gene encoding an antigen recognized by cytolytic T lymphocytes on the autologous tumor cells of a melanoma patient, AVL3. The gen…

  Authors: Francesca Schiavetti, Joëlle Thonnard, Didier Colau, Thierry Boon, Pierre G Coulie

  Source: Cancer research. 2002 Oct 1

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• Cytolytic T-cell responses of cancer patients vaccinated with a MAGE antigen.

  Cancer-germline' genes such as the MAGE gene family are expressed in many tumors and in male germline cells but not in normal tissues. They encode sha…

  Authors: Pierre G Coulie, Vaios Karanikas, Christophe Lurquin, Didier Colau, Thierry Connerotte, Takeshi Hanagiri, Aline Van Pel, Sophie Lucas, Danièle Godelaine, Christophe Lonchay,…

  Source: Immunological reviews. 2002 Oct

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• Selective cancer-germline gene expression in pediatric brain tumors.

  Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expres…

  Authors: Joannes F M Jacobs, Oliver M Grauer, Francis Brasseur, Peter M Hoogerbrugge, Pieter Wesseling, Corrie E Gidding, Mandy W M M van de Rakt, Carl G Figdor, Pierre G Coulie, I Jolanda M de Vries,…

  Source: Journal of neuro-oncology. 2008 Jul

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