1 to 10 of 69 literature results

• Evolutionarily conserved amino acids that control TCR-MHC interaction.

  The rules for the conserved reaction of alphabeta T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorl…

  Authors: Philippa Marrack, James P Scott-Browne, Shaodong Dai, Laurent Gapin, John W Kappler

  Source: Annual review of immunology. 2008

  View Full Text

• Control of T cell viability.

  The factors affecting T cell viability vary depending on the type and status of the T cell involved. Naive T cells die via a Bcl-2/Bim dependent route…

  Authors: Philippa Marrack, John Kappler

  Source: Annual review of immunology. 2004

  View Full Text

• Chromogranin A is an autoantigen in type 1 diabetes.

  Autoreactive CD4(+) T cells are involved in the pathogenesis of many autoimmune diseases, but the antigens that stimulate their responses have been di…

  Authors: Brian D Stadinski, Thomas Delong, Nichole Reisdorph, Richard Reisdorph, Roger L Powell, Michael Armstrong, Jon D Piganelli, Gene Barbour, Brenda Bradley, Frances Crawford,…

  Source: Nature immunology. 2010 Mar

  View Full Text

• Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection.

  An alphabeta T-cell response depends on the recognition of antigen plus major histocompatibility complex (MHC) proteins by its antigen receptor (TCR).…

  Authors: James P Scott-Browne, Janice White, John W Kappler, Laurent Gapin, Philippa Marrack

  Source: Nature. 2009 Apr 23

  View Free Full Text

• Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells.

  Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch sh…

  Authors: Baoli Yang, Denise L Gay, Megan K L MacLeod, Xiao Cao, Tamara Hala, Eileen M Sweezer, John Kappler, Philippa Marrack, Paula M Oliver

  Source: Nature immunology. 2008 Dec

  View Full Text

• How do adjuvants work? Important considerations for new generation adjuvants.

  In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune…

  Authors: Amy S McKee, Michael W Munks, Philippa Marrack

  Source: Immunity. 2007 Nov

  View Full Text

• Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide.

  T cell receptors (TCRs) bind complexes of cognate major histocompatibility complex (MHC) and peptide at relatively low affinities (1-200 microM). Neve…

  Authors: Eric S Huseby, Frances Crawford, Janice White, Philippa Marrack, John W Kappler

  Source: Nature immunology. 2006 Nov

  View Full Text

• Germline-encoded recognition of diverse glycolipids by natural killer T cells.

  Natural killer T cells expressing 'invariant' T cell receptor alpha-chains (TCRalpha chains) containing variable (V) and joining (J) region V(alpha)14…

  Authors: James P Scott-Browne, Jennifer L Matsuda, Thierry Mallevaey, Janice White, Natalie A Borg, James McCluskey, Jamie Rossjohn, John Kappler, Philippa Marrack, Laurent Gapin

  Source: Nature immunology. 2007 Oct

  View Full Text

• Apoptosis and the homeostatic control of immune responses.

  Normal homeostasis of the immune system is controlled by a balance of production and death. During an immune response, homeostasis is disturbed as ant…

  Authors: David Hildeman, Trine Jorgensen, John Kappler, Philippa Marrack

  Source: Current opinion in immunology. 2007 Oct

  View Full Text

• How the T cell repertoire becomes peptide and MHC specific.

  T cells bearing alphabeta T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility pro…

  Authors: Eric S Huseby, Janice White, Frances Crawford, Tibor Vass, Dean Becker, Clemencia Pinilla, Philippa Marrack, John W Kappler

  Source: Cell. 2005 Jul 29

  View Full Text