1 to 5 of 5 literature results

• A spatially and temporally restricted mouse model of soft tissue sarcoma.

  Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we h…

  Authors: David G Kirsch, Daniela M Dinulescu, John B Miller, Jan Grimm, Philip M Santiago, Nathan P Young, G Petur Nielsen, Bradley J Quade, Christopher J Chaber, Christian P Schultz,…

  Source: Nature medicine. 2007 Aug

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• Imaging primary lung cancers in mice to study radiation biology.

  PURPOSE: To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor respon…

  Authors: David G Kirsch, Jan Grimm, Alexander R Guimaraes, Gregory R Wojtkiewicz, Bradford A Perez, Philip M Santiago, Nikolas K Anthony, Thomas Forbes, Karen Doppke, Ralph Weissleder,…

  Source: International journal of radiation oncology, biology, physics. 2010 Mar 15

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• Elaboration of B gene function to include the identity of novel floral organs in the lower eudicot Aquilegia.

  The basal eudicot Aquilegia (columbine) has an unusual floral structure that includes two morphologically distinct whorls of petaloid organs and a cle…

  Authors: Elena M Kramer, Lynn Holappa, Billie Gould, M Alejandra Jaramillo, Dimitriy Setnikov, Philip M Santiago

  Source: The Plant cell. 2007 Mar

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• p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.

  Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the targe…

  Authors: David G Kirsch, Philip M Santiago, Emmanuelle di Tomaso, Julie M Sullivan, Wu-Shiun Hou, Talya Dayton, Laura B Jeffords, Pooja Sodha, Kim L Mercer, Rhianna Cohen,…

  Source: Science (New York, N.Y.). 2010 Jan 29

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• Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.

  Using gene expression profiling, we identified cathepsin cysteine proteases as highly up-regulated genes in a mouse model of human lung adenocarcinoma…

  Authors: Jan Grimm, David G Kirsch, Stephen D Windsor, Carla F Bender Kim, Philip M Santiago, Vasilis Ntziachristos, Tyler Jacks, Ralph Weissleder

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Oct 4

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