1 to 8 of 8 literature results

• Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

  Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated l…

  Authors: Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski, Aimee Landry, Philippe Goyette, Michael C Zody, Jennifer L Hall, Steven R Brant, Judy H Cho,…

  Source: Nature genetics. 2008 Sep

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• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

  We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of associa…

  Authors: John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta,…

  Source: Nature genetics. 2007 May

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• DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

  PDZ domain containing molecular scaffolds plays a central role in organizing synaptic junctions. Observations in Drosophila and mammalian cells have i…

  Authors: Zhifang Cao, Alan Huett, Petric Kuballa, Cosmas Giallourakis, Ramnik J Xavier

  Source: Cellular signalling. 2008 Jan

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• Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.

  The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tu…

  Authors: Arnd Hengstermann, Michael A D'silva, Petric Kuballa, Karin Butz, Felix Hoppe-Seyler, Martin Scheffner

  Source: Journal of virology. 2005 Jul

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• The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins.

  The E6 oncoprotein of human papillomaviruses associated with cervical cancer targets the tumor suppressor p53 and several other cellular proteins incl…

  Authors: Petric Kuballa, Konstantin Matentzoglu, Martin Scheffner

  Source: The Journal of biological chemistry. 2007 Jan 5

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• Porcine purple acid phosphatase: heterologous expression, characterization, and proteolytic analysis.

  Uteroferrin is an iron-binding glycoprotein, which is abundantly synthesized in porcine uterine glandular endometrium and believed to be involved in m…

  Authors: Joseph Itor Naseri, Ngoc Thanh Truong, Jens Hörentrup, Petric Kuballa, Andreas Vogel, Annette Rompel, Friedrich Spener, Bernt Krebs

  Source: Archives of biochemistry and biophysics. 2004 Dec 1

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• Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

  The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide assoc…

  Authors: Petric Kuballa, Alan Huett, John D Rioux, Mark J Daly, Ramnik J Xavier

  Source: PloS one. 2008

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• A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

  Autophagy is a conserved cellular process required for the removal of defective organelles, protein aggregates, and intracellular pathogens. We used a…

  Authors: Alan Huett, Aylwin Ng, Zhifang Cao, Petric Kuballa, Masaaki Komatsu, Mark J Daly, Daniel K Podolsky, Ramnik J Xavier

  Source: Journal of immunology (Baltimore, Md. : 1950). 2009 Apr 15

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