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Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…
Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar
Source: Nature. 2009 Aug 6
View Full TextAuthors: Peter M Visscher
Source: Nature genetics. 2008 May
View Full TextGenome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…
Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…
Source: Nature. 2009 Oct 8
View Full TextObserved linkage disequilibrium (LD) between genetic markers in different populations descended independently from a common ancestral population can b…
Authors: John A Sved, Allan F McRae, Peter M Visscher
Source: American journal of human genetics. 2008 Dec
View Free Full TextTwin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotyp…
Authors: Zachary A Kaminsky, Thomas Tang, Sun-Chong Wang, Carolyn Ptak, Gabriel H T Oh, Albert H C Wong, Laura A Feldcamp, Carl Virtanen, Jonas Halfvarson, Curt Tysk,…
Source: Nature genetics. 2009 Feb
View Full TextMost common diseases are caused by multiple genetic and environmental factors. In the last 2 years, genome-wide association studies (GWAS) have identi…
Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher
Source: Current opinion in genetics & development. 2008 Jun
View Full TextWe report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10…
Authors: Beben Benyamin, Manuel A R Ferreira, Gonneke Willemsen, Scott Gordon, Rita P S Middelberg, Brian P McEvoy, Jouke-Jan Hottenga, Anjali K Henders, Megan J Campbell, Leanne Wallace,…
Source: Nature genetics. 2009 Oct 11
View Full TextThe current paradigm within genetic diagnostics is to test individuals only at loci known to affect risk of complex disease-yet the technology exists …
Authors: David M Evans, Peter M Visscher, Naomi R Wray
Source: Human molecular genetics. 2009 Sep 15
View Full TextEmpirical studies suggest that the effect sizes of individual causal risk alleles underlying complex genetic diseases are small, with most genotype re…
Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher
Source: Genome research. 2007 Oct
View Free Full TextWe develop expressions for the power to detect associations between parental genotypes and offspring phenotypes for quantitative traits. Three differe…
Authors: Stephen F Chenoweth, Peter M Visscher
Source: Genetics. 2009 Feb
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