1 to 10 of 104 literature results

• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

  View Full Text

• Sizing up human height variation.

  Authors: Peter M Visscher

  Source: Nature genetics. 2008 May

  View Full Text

• Finding the missing heritability of complex diseases.

  Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…

  Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…

  Source: Nature. 2009 Oct 8

  View Full Text

• Divergence between human populations estimated from linkage disequilibrium.

  Observed linkage disequilibrium (LD) between genetic markers in different populations descended independently from a common ancestral population can b…

  Authors: John A Sved, Allan F McRae, Peter M Visscher

  Source: American journal of human genetics. 2008 Dec

  View Free Full Text

• DNA methylation profiles in monozygotic and dizygotic twins.

  Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotyp…

  Authors: Zachary A Kaminsky, Thomas Tang, Sun-Chong Wang, Carolyn Ptak, Gabriel H T Oh, Albert H C Wong, Laura A Feldcamp, Carl Virtanen, Jonas Halfvarson, Curt Tysk,…

  Source: Nature genetics. 2009 Feb

  View Full Text

• Prediction of individual genetic risk of complex disease.

  Most common diseases are caused by multiple genetic and environmental factors. In the last 2 years, genome-wide association studies (GWAS) have identi…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Current opinion in genetics & development. 2008 Jun

  View Full Text

• Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.

  We report a genome-wide association study to iron status. We identify an association of SNPs in TPMRSS6 to serum iron (rs855791, combined P = 1.5 x 10…

  Authors: Beben Benyamin, Manuel A R Ferreira, Gonneke Willemsen, Scott Gordon, Rita P S Middelberg, Brian P McEvoy, Jouke-Jan Hottenga, Anjali K Henders, Megan J Campbell, Leanne Wallace,…

  Source: Nature genetics. 2009 Oct 11

  View Full Text

• Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk.

  The current paradigm within genetic diagnostics is to test individuals only at loci known to affect risk of complex disease-yet the technology exists …

  Authors: David M Evans, Peter M Visscher, Naomi R Wray

  Source: Human molecular genetics. 2009 Sep 15

  View Full Text

• Prediction of individual genetic risk to disease from genome-wide association studies.

  Empirical studies suggest that the effect sizes of individual causal risk alleles underlying complex genetic diseases are small, with most genotype re…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Genome research. 2007 Oct

  View Free Full Text

• Association mapping in outbred populations: power and efficiency when genotyping parents and phenotyping progeny.

  We develop expressions for the power to detect associations between parental genotypes and offspring phenotypes for quantitative traits. Three differe…

  Authors: Stephen F Chenoweth, Peter M Visscher

  Source: Genetics. 2009 Feb

  View Free Full Text