1 to 10 of 117 literature results

• Recent advances in the genetics of autoimmune disease.

  Extraordinary technical advances in the field of human genetics over the past few years have catalyzed an explosion of new information about the genet…

  Authors: Peter K Gregersen, Lina M Olsson

  Source: Annual review of immunology. 2009

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• Closing the gap between genotype and phenotype.

  Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A …

  Authors: Peter K Gregersen

  Source: Nature genetics. 2009 Sep

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• Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

  The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling…

  Authors: Stacy L Musone, Kimberly E Taylor, Timothy T Lu, Joanne Nititham, Ricardo C Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A Petri, M Ilyas Kamboh, Susan Manzi,…

  Source: Nature genetics. 2008 Sep

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• REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

  We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an associatio…

  Authors: Peter K Gregersen, Chistopher I Amos, Annette T Lee, Yue Lu, Elaine F Remmers, Daniel L Kastner, Michael F Seldin, Lindsey A Criswell, Robert M Plenge, V Michael Holers,…

  Source: Nature genetics. 2009 Jul

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• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

  Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide …

  Authors: Mark S Silverberg, Judy H Cho, John D Rioux, Dermot P B McGovern, Jing Wu, Vito Annese, Jean-Paul Achkar, Philippe Goyette, Regan Scott, Wei Xu,…

  Source: Nature genetics. 2009 Feb

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• Accounting for ancestry: population substructure and genome-wide association studies.

  Accounting for the genetic substructure of human populations has become a major practical issue for studying complex genetic disorders. Allele frequen…

  Authors: Chao Tian, Peter K Gregersen, Michael F Seldin

  Source: Human molecular genetics. 2008 Oct 15

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• A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

  Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional…

  Authors: Vesela Gateva, Johanna K Sandling, Geoff Hom, Kimberly E Taylor, Sharon A Chung, Xin Sun, Ward Ortmann, Roman Kosoy, Ricardo C Ferreira, Gunnel Nordmark,…

  Source: Nature genetics. 2009 Nov

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• Gaining insight into PTPN22 and autoimmunity.

  Authors: Peter K Gregersen

  Source: Nature genetics. 2005 Dec

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• Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.

  OBJECTIVE: Recent studies have identified a number of novel rheumatoid arthritis (RA) susceptibility loci in Caucasian populations. The aim of this st…

  Authors: Hye-Soon Lee, Benjamin D Korman, Julie M Le, Daniel L Kastner, Elaine F Remmers, Peter K Gregersen, Sang-Cheol Bae

  Source: Arthritis and rheumatism. 2009 Feb

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• Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.

  Rheumatoid arthritis (RA), like other autoimmune diseases, has a complex genetic basis. Rapid technical advances in high-throughput genotyping and ana…

  Authors: Peter K Gregersen

  Source: Immunological reviews. 2005 Apr

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