1 to 6 of 6 literature results

• Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

  OBJECTIVE: Systemic lupus erythematosus is a multifactorial disease with a strong genetic component. Previous studies have shown that a 129-derived ch…

  Authors: Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Peter J Norsworthy, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis and rheumatism. 2008 Jul

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• Familial clustering of non-nuclear autoantibodies and C3 and C4 complement components in systemic lupus erythematosus.

  OBJECTIVE: To determine whether key features of systemic lupus erythematosus (SLE), namely, production of non-nuclear antibodies (anti-C1q and anticar…

  Authors: Saowalak Hunnangkul, Dorothea Nitsch, Benjamin Rhodes, Sapna Chadha, Cheri A Roberton, Pedro Pessôa-Lopes, Peter J Norsworthy, Michelle M A Fernando, Peter Charles, Charles Mackworth-Young,…

  Source: Arthritis and rheumatism. 2008 Apr

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• C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.

  C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus …

  Authors: Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Peter J Norsworthy, Mark J Walport, H Terence Cook, Marina Botto

  Source: Molecular immunology. 2008 Feb

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• Anti-alphaGal-dependent complement-mediated cytotoxicity in metastatic melanoma.

  Antibodies to the cell surface disaccharide galactose(alpha1,3)galactose (alphaGal) are the most prevalent natural antibodies in human serum. The anti…

  Authors: James M G Larkin, Peter J Norsworthy, Roger P A'Hern, Tim G Eisen, Martin E Gore, Colin D Porter

  Source: Melanoma research. 2006 Apr

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• Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.

  Human CD93 (known as C1qRp) has been shown to be a phagocytic receptor involved in the in vitro C1q-dependent enhancement of phagocytosis. However, bi…

  Authors: Peter J Norsworthy, Liliane Fossati-Jimack, Josefina Cortes-Hernandez, Philip R Taylor, Anne E Bygrave, Richard D Thompson, Sussan Nourshargh, Mark J Walport, Marina Botto

  Source: Journal of immunology (Baltimore, Md. : 1950). 2004 Mar 15

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• SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience.

  Authors: Puja Mehta, Peter J Norsworthy, Angela E Hall, Susan J Kelly, Mark J Walport, Marina Botto, Matthew C Pickering

  Source: Rheumatology (Oxford, England). 2009 Dec 4

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