1 to 6 of 6 literature results

• The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Ev…

  Authors: Anthony P Manderson, Francesco Carlucci, Peter J Lachmann, Robert A Lazarus, Richard J Festenstein, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis research & therapy. 2006

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• The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins.

  Streptococcal inhibitor of complement (SIC) is a 31 kDa extracellular protein produced by a few highly virulent strains of Streptococcus pyogenes (in …

  Authors: Barbara A Fernie-King, David J Seilly, Peter J Lachmann

  Source: Immunology. 2004 Apr

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• Streptococcal inhibitor of complement inhibits two additional components of the mucosal innate immune system: secretory leukocyte proteinase inhibitor and lysozyme.

  Streptococcal inhibitor of complement (SIC) is a 31-kDa extracellular protein of a few, very virulent, strains of Streptococcus pyogenes (particularly…

  Authors: Barbara A Fernie-King, David J Seilly, Alexandra Davies, Peter J Lachmann

  Source: Infection and immunity. 2002 Sep

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• Stem cell therapy: medical advance or moral challenge?

  My professional lifetime has seen progress in the biomedical sciences that beggars belief. This has lead to astonishing advances in the ability to pre…

  Authors: Peter J Lachmann

  Source: Comptes rendus biologies. 2002 Oct

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• Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities.

  Streptococcal inhibitor of complement" (SIC) and "distantly related to SIC" (DRS) are related virulence factors secreted by M1 and M12 strains of GAS,…

  Authors: Barbara A Fernie-King, David J Seilly, Michael J Binks, Kadaba S Sriprakash, Peter J Lachmann

  Source: Microbes and infection / Institut Pasteur. 2007 Mar

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• Attribution of the various inhibitory actions of the streptococcal inhibitor of complement (SIC) to regions within the molecule.

  Some strains of Streptococcus pyogenes secrete a virulence factor called the streptococcal inhibitor of complement (SIC) function. SIC is a polyfuncti…

  Authors: Michael J Binks, Barbara A Fernie-King, David J Seilly, Peter J Lachmann, Kadaba S Sriprakash

  Source: The Journal of biological chemistry. 2005 May 20

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