1 to 10 of 39 literature results

• A survey of genetic human cortical gene expression.

  It is widely assumed that genetic differences in gene expression underpin much of the difference among individuals and many of the quantitative traits…

  Authors: Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath,…

  Source: Nature genetics. 2007 Dec

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

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• Genetic control of human brain transcript expression in Alzheimer disease.

  We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. W…

  Authors: Jennifer A Webster, J Raphael Gibbs, Jennifer Clarke, Monika Ray, Weixiong Zhang, Peter Holmans, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem,…

  Source: American journal of human genetics. 2009 Apr

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• Comparison of methods for combining case-control and family-based association studies.

  OBJECTIVES: Combining the analysis of family-based samples with unrelated individuals can enhance the power of genetic association studies. Various co…

  Authors: Beate Glaser, Peter Holmans

  Source: Human heredity. 2009

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• Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.

  Linkage between developmental dyslexia (DD) and chromosome 6p has been replicated in a number of independent samples. Recent attempts to identify the …

  Authors: Natalie Cope, Denise Harold, Gary Hill, Valentina Moskvina, Jim Stevenson, Peter Holmans, Michael J Owen, Michael C O'Donovan, Julie Williams

  Source: American journal of human genetics. 2005 Apr

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• Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.

  BACKGROUND: We reported genome-wide significant linkage on chromosome 15q25.3-26.2 to recurrent early-onset major depressive disorder (MDD-RE). Here w…

  Authors: Ranjana Verma, Peter Holmans, James A Knowles, Deepak Grover, Oleg V Evgrafov, Raymond R Crowe, William A Scheftner, Myrna M Weissman, J Raymond DePaulo, James B Potash,…

  Source: Biological psychiatry. 2008 Jun 15

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• Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13.

  CONTEXT: Traditionally, the search for genes involved in predisposition to major psychoses has proceeded with separate studies of schizophrenia and bi…

  Authors: Marian L Hamshere, Phil Bennett, Nigel Williams, Ricardo Segurado, Alastair Cardno, Nadine Norton, David Lambert, Hywel Williams, George Kirov, Aiden Corvin,…

  Source: Archives of general psychiatry. 2005 Oct

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• Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.

  Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility…

  Authors: Yonghong Li, Andrew Grupe, Charles Rowland, Peter Holmans, Ricardo Segurado, Richard Abraham, Lesley Jones, Joseph Catanese, David Ross, Kevin Mayo,…

  Source: Human molecular genetics. 2008 Mar 1

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