10 literature results

• Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

  Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL…

  Authors: Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,…

  Source: Nature medicine. 2009 Jan

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• Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

  Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a promising target for d…

  Authors: Teresa Palomero, Maria Luisa Sulis, Maria Cortina, Pedro J Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L Perkins,…

  Source: Nature medicine. 2007 Oct

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• NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

  Heterodimerization domain (HD) mutations in NOTCH1 induce ligand-independent activation of the receptor and contribute to the pathogenesis of one-thir…

  Authors: Maria Luisa Sulis, Odette Williams, Teresa Palomero, Valeria Tosello, Sasikala Pallikuppam, Pedro J Real, Kelly Barnes, Linda Zuurbier, Jules P Meijerink, Adolfo A Ferrando

  Source: Blood. 2008 Aug 1

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• Defective binding of transcriptional repressor ZEB via DNA methylation contributes to increased constitutive levels of p73 in Fanconi anemia cells.

  Little is known about the molecular mediators of the Fanconi anemia (FA) pathway involved in the machinery that maintains genomic integrity. Here, we …

  Authors: Carlos Pipaon, Pedro J Real, Jose L Fernandez-Luna

  Source: FEBS letters. 2005 Aug 29

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• Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L.

  Epidermal growth factor receptor-1 (EGFR) and EGFR-2 (HER2) have become major targets for cancer treatment. Blocking antibodies and small-molecule inh…

  Authors: Pedro J Real, Adalberto Benito, Jorge Cuevas, Maria T Berciano, Ana de Juan, Paul Coffer, Javier Gomez-Roman, Miguel Lafarga, Jose M Lopez-Vega, Jose L Fernandez-Luna

  Source: Cancer research. 2005 Sep 15

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• Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells.

  BH3-only proteins are required for execution of apoptotic cell death. We have found that one of these proteins, Bik, is strongly induced in cancer cel…

  Authors: Pedro J Real, Cristina Sanz, Olga Gutierrez, Carlos Pipaon, Ana M Zubiaga, Jose L Fernandez-Luna

  Source: FEBS letters. 2006 Oct 30

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• Identification of c-Kit gene mutations in patients with polycythemia vera.

  Imatinib mesylate has recently been reported to have clinical activity in the treatment of polycythemia vera (PV), suggesting the involvement of one o…

  Authors: Ana Fontalba, Pedro J Real, Jose L Fernandez-Luna, Xabier Agirre, Felipe Prosper, Carlos Richard

  Source: Leukemia research. 2006 Oct

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• Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.

  Disruption of apoptosis may allow metastatic cell survival and confer resistance to chemotherapeutic drugs. We have analysed the molecular pathways th…

  Authors: Pedro J Real, Angels Sierra, Ana De Juan, Jose C Segovia, Jose M Lopez-Vega, Jose L Fernandez-Luna

  Source: Oncogene. 2002 Oct 31

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• A novel role for proline- and acid-rich basic region leucine zipper (PAR bZIP) proteins in the transcriptional regulation of a BH3-only proapoptotic gene.

  Proline- and acid-rich (PAR) basic region leucine zipper (bZIP) proteins thyrotroph embryonic factor (TEF), D-site-binding protein (DBP), and hepatic …

  Authors: Adalberto Benito, Olga Gutierrez, Carlos Pipaon, Pedro J Real, Frederic Gachon, Alistair E Ritchie, Jose L Fernandez-Luna

  Source: The Journal of biological chemistry. 2006 Dec 15

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• NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.

  The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during …

  Authors: Teresa Palomero, Wei Keat Lim, Duncan T Odom, Maria Luisa Sulis, Pedro J Real, Adam Margolin, Kelly C Barnes, Jennifer O'Neil, Donna Neuberg, Andrew P Weng,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Nov 28

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