1 to 10 of 49 literature results

• Establishing the program of origin firing during S phase in fission Yeast.

  Initiation of eukaryotic DNA synthesis occurs at origins of replication that are utilized with characteristic times and frequencies during S phase. We…

  Authors: Pei-Yun Jenny Wu, Paul Nurse

  Source: Cell. 2009 Mar 6

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• Cell Division Intersects with Cell Geometry.

  Single-celled organisms monitor cell geometry and use this information to control cell division. Such geometry-sensing mechanisms control both the dec…

  Authors: James B Moseley, Paul Nurse

  Source: Cell. 2010 Jul 23

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• US biomedical research under siege.

  The stagnation of biomedical research funding in the US is placing great pressure on the research enterprise. It is time to consider some radical solu…

  Authors: Paul Nurse

  Source: Cell. 2006 Jan 13

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• Science on the streets of the Big Apple.

  A five-day festival of science takes place this week at venues across New York City. The festival features not only leading researchers from New York …

  Authors: Brian Greene, Paul Nurse

  Source: Cell. 2008 May 30

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• A spatial gradient coordinates cell size and mitotic entry in fission yeast.

  Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1 (refs 1-4). The pro…

  Authors: James B Moseley, Adeline Mayeux, Anne Paoletti, Paul Nurse

  Source: Nature. 2009 Jun 11

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• Cdk1 and cell morphology: connections and directions.

  Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle…

  Authors: James B Moseley, Paul Nurse

  Source: Current opinion in cell biology. 2009 Feb

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• Life, logic and information.

  Authors: Paul Nurse

  Source: Nature. 2008 Jul 24

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• Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

  DNA replication is initiated by recruitment of Cdc18 to origins. During S phase, CDK-dependent destruction of Cdc18 occurs. We show that when DNA repl…

  Authors: Damien Hermand, Paul Nurse

  Source: Molecular cell. 2007 May 25

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• TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

  The coupling of growth to cell cycle progression allows eukaryotic cells to divide at particular sizes depending on nutrient availability. In fission …

  Authors: Janni Petersen, Paul Nurse

  Source: Nature cell biology. 2007 Nov

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• Self-organization of interphase microtubule arrays in fission yeast.

  Microtubule organization is key to eukaryotic cell structure and function. In most animal cells, interphase microtubules organize around the centrosom…

  Authors: Rafael E Carazo-Salas, Paul Nurse

  Source: Nature cell biology. 2006 Oct

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