1 to 10 of 15 literature results

• p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.

  The CDKN2b-CDKN2a locus on chromosome 9p21 in human (chromosome 4 in mouse) is frequently lost in cancer. The locus encodes three cell cycle inhibitor…

  Authors: Paul Krimpenfort, Annemieke Ijpenberg, Ji-Ying Song, Martin van der Valk, Martijn Nawijn, John Zevenhoven, Anton Berns

  Source: Nature. 2007 Aug 23

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• A conditional mouse model for malignant mesothelioma.

  Malignant mesothelioma is a devastating disease that has been associated with loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB …

  Authors: Johan Jongsma, Erwin van Montfort, Marc Vooijs, John Zevenhoven, Paul Krimpenfort, Martin van der Valk, Marc van de Vijver, Anton Berns

  Source: Cancer cell. 2008 Mar

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• Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

  Metastatic disease is the primary cause of death in breast cancer, the most common malignancy in Western women. Loss of E-cadherin is associated with …

  Authors: Patrick W B Derksen, Xiaoling Liu, Francis Saridin, Hanneke van der Gulden, John Zevenhoven, Bastiaan Evers, Judy R van Beijnum, Arjan W Griffioen, Jacqueline Vink, Paul Krimpenfort,…

  Source: Cancer cell. 2006 Nov

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• Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.

  The cyclin dependent kinase (CDK) inhibitors p15, p16, p21, and p27 are frequently deleted, silenced, or downregulated in many malignancies. Inactivat…

  Authors: Jaap Kool, Anthony G Uren, Carla P Martins, Daoud Sie, Jeroen de Ridder, Geoffrey Turner, Miranda van Uitert, Konstantin Matentzoglu, Wendy Lagcher, Paul Krimpenfort,…

  Source: Cancer research. 2010 Jan 15

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• An inducible mouse model of melanoma expressing a defined tumor antigen.

  Cancer immunotherapy based on vaccination with defined tumor antigens has not yet shown strong clinical efficacy, despite promising results in preclin…

  Authors: Ivo J Huijbers, Paul Krimpenfort, Patrick Chomez, Martin A van der Valk, Ji-Ying Song, Else-Marit Inderberg-Suso, Anne-Marie Schmitt-Verhulst, Anton Berns, Benoît J Van den Eynde

  Source: Cancer research. 2006 Mar 15

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• The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice.

  The ability to noninvasively quantitate tumor burden from conditional (Cre/loxP-dependent) mouse cancer models would greatly increase their range of u…

  Authors: Scott K Lyons, Ralph Meuwissen, Paul Krimpenfort, Anton Berns

  Source: Cancer research. 2003 Nov 1

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• Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

  The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a nove…

  Authors: Xiaoqian Ma, Angelique C Ziel-van der Made, Binha Autar, Hetty A van der Korput, Marcel Vermeij, Petra van Duijn, Kitty B Cleutjens, Ronald de Krijger, Paul Krimpenfort, Anton Berns,…

  Source: Cancer research. 2005 Jul 1

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• Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues.

  Ligand-activated Cre recombinases are widely used for studying gene function in vitro and in conditional mouse models. To compare ligand-dependent Cre…

  Authors: Dorothe Hameyer, Ate Loonstra, Leonid Eshkind, Steffen Schmitt, Cecilia Antunes, Annemiek Groen, Eric Bindels, Jos Jonkers, Paul Krimpenfort, Ralph Meuwissen,…

  Source: Physiological genomics. 2007 Sep 19

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• TCR down-regulation controls virus-specific CD8+ T cell responses.

  The CD3gamma di-leucine-based motif plays a central role in TCR down-regulation. However, little is understood about the role of the CD3gamma di-leuci…

  Authors: Charlotte Menné Bonefeld, Mariëlle Haks, Bodil Nielsen, Marina von Essen, Lasse Boding, Ann Kathrine Hansen, Jeppe Madura Larsen, Niels Odum, Paul Krimpenfort, Ada Kruisbeek,…

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Dec 1

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• ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.

  Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and i…

  Authors: Linan Ha, Takeshi Ichikawa, Miriam Anver, Ross Dickins, Scott Lowe, Norman E Sharpless, Paul Krimpenfort, Ronald A Depinho, Dorothy C Bennett, Elena V Sviderskaya,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Jun 26

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