1 to 10 of 55 literature results

• HIV-1 at 25.

  In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted th…

  Authors: David D Ho, Paul D Bieniasz

  Source: Cell. 2008 May 16

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• Imaging the biogenesis of individual HIV-1 virions in live cells.

  Observations of individual virions in live cells have led to the characterization of their attachment, entry and intracellular transport. However, the…

  Authors: Nolwenn Jouvenet, Paul D Bieniasz, Sanford M Simon

  Source: Nature. 2008 Jul 10

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• Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

  Human cells possess an antiviral activity that inhibits the release of retrovirus particles, and other enveloped virus particles, and is antagonized b…

  Authors: Stuart J D Neil, Trinity Zang, Paul D Bieniasz

  Source: Nature. 2008 Jan 24

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• Intrinsic immunity: a front-line defense against viral attack.

  In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed ge…

  Authors: Paul D Bieniasz

  Source: Nature immunology. 2004 Nov

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• Tetherin inhibits HIV-1 release by directly tethering virions to cells.

  Tetherin is an interferon-induced protein whose expression blocks the release of HIV-1 and other enveloped viral particles. The underlying mechanism b…

  Authors: David Perez-Caballero, Trinity Zang, Alaleh Ebrahimi, Matthew W McNatt, Devon A Gregory, Marc C Johnson, Paul D Bieniasz

  Source: Cell. 2009 Oct 30

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• Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

  Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mech…

  Authors: Matthew J Evans, Thomas von Hahn, Donna M Tscherne, Andrew J Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A McKeating, Paul D Bieniasz, Charles M Rice

  Source: Nature. 2007 Apr 12

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• Integration target site selection by a resurrected human endogenous retrovirus.

  At least 8% of the human genome was formed by integration of retroviral DNA sequences. Here we analyze the forces directing the accumulation of human …

  Authors: Troy Brady, Young Nam Lee, Keshet Ronen, Nirav Malani, Charles C Berry, Paul D Bieniasz, Frederic D Bushman

  Source: Genes & development. 2009 Mar 1

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• No effect of endogenous TRIM5alpha on HIV-1 production.

  Authors: Fengwen Zhang, David Perez-Caballero, Theodora Hatziioannou, Paul D Bieniasz

  Source: Nature medicine. 2008 Mar

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• Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.

  Many mammalian species express restriction factors that confer host resistance to retroviral infection. Here we show that HIV-1 sensitivity to restric…

  Authors: Greg J Towers, Theodora Hatziioannou, Simone Cowan, Stephen P Goff, Jeremy Luban, Paul D Bieniasz

  Source: Nature medicine. 2003 Sep

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• Hypermutation of an ancient human retrovirus by APOBEC3G.

  Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome, but all are remnants of ancient retroviral infections and harbor …

  Authors: Young Nam Lee, Michael H Malim, Paul D Bieniasz

  Source: Journal of virology. 2008 Sep

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