1 to 10 of 17 literature results

• Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.

  Macrophage low-density lipoprotein receptor-related protein (LRP) mediates internalization of remnant lipoproteins, and it is generally thought that b…

  Authors: Cheryl D Overton, Patricia G Yancey, Amy S Major, MacRae F Linton, Sergio Fazio

  Source: Circulation research. 2007 Mar 16

  View Full Text

• Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays important roles in lipid metabolism, inflammation, and atherosclero…

  Authors: Vladimir R Babaev, Hiroyuki Ishiguro, Lei Ding, Patricia G Yancey, Dwayne E Dove, William J Kovacs, Clay F Semenkovich, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2007 Sep 18

  View Full Text

• Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.

  BACKGROUND: Scavenger receptor class B type I (SR-BI) is expressed in macrophages, where it has been proposed to facilitate cholesterol efflux. Howeve…

  Authors: Wenwu Zhang, Patricia G Yancey, Yan Ru Su, Vladimir R Babaev, Yuomin Zhang, Sergio Fazio, MacRae F Linton

  Source: Circulation. 2003 Nov 4

  View Full Text

• Self-association of human PCSK9 correlates with its LDLR-degrading activity.

  Genetic studies have demonstrated an important role for proprotein convertase subtilisin/kexin type 9 (PCSK9) as a determinant of plasma cholesterol l…

  Authors: Daping Fan, Patricia G Yancey, Shenfeng Qiu, Lei Ding, Edwin J Weeber, MacRae F Linton, Sergio Fazio

  Source: Biochemistry. 2008 Feb 12

  View Free Full Text

• Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI.

  Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated…

  Authors: Patricia G Yancey, W Gray Jerome, Hong Yu, Evelyn E Griffin, Brian E Cox, Vladimir R Babaev, Sergio Fazio, MacRae F Linton

  Source: Journal of lipid research. 2007 May

  View Full Text

• Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells.

  We have investigated apolipoprotein E (apoE) recycling in Chinese hamster ovary (CHO) cells, a peripheral cell that does not produce lipoproteins or e…

  Authors: Nicole A Braun, Peter J Mohler, Karl H Weisgraber, Alyssa H Hasty, MacRae F Linton, Patricia G Yancey, Yan Ru Su, Sergio Fazio, Larry L Swift

  Source: Journal of lipid research. 2006 Jun

  View Full Text

• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.

  Cyclooxygenase (COX) 2 is expressed in atherosclerotic lesions. We have previously reported that selective inhibition of COX-2 reduces early atheroscl…

  Authors: Michael E Burleigh, Vladimir R Babaev, Patricia G Yancey, Amy S Major, Jennifer L McCaleb, John A Oates, Jason D Morrow, Sergio Fazio, Macrae F Linton

  Source: Journal of molecular and cellular cardiology. 2005 Sep

  View Full Text

• SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome.

  Alagille syndrome is associated with bile duct paucity resulting in liver disease. Patients can be divided into mildly and severely icteric groups, wi…

  Authors: Patricia G Yancey, Bela F Asztalos, Nicolas Stettler, David Piccoli, David L Williams, Margery A Connelly, George H Rothblat

  Source: Journal of lipid research. 2004 Sep

  View Full Text

• In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux.

  The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-medi…

  Authors: Patricia G Yancey, Masa-aki Kawashiri, Ryan Moore, Jane M Glick, David L Williams, Margery A Connelly, Daniel J Rader, George H Rothblat

  Source: Journal of lipid research. 2004 Feb

  View Full Text

• Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.

  Low levels of transgenic mouse apolipoprotein E (apoE) suppress atherosclerosis in apoE knockout (apoE-/-) mice without normalizing plasma cholesterol…

  Authors: Fayanne E Thorngate, Patricia G Yancey, Ginny Kellner-Weibel, Lawrence L Rudel, George H Rothblat, David L Williams

  Source: Journal of lipid research. 2003 Dec

  View Full Text