1 to 10 of 16 literature results

• Prolyl 4-hydroxylation regulates Argonaute 2 stability.

  Human Argonaute (Ago) proteins are essential components of the RNA-induced silencing complexes (RISCs). Argonaute 2 (Ago2) has a P-element-induced wim…

  Authors: Hank H Qi, Pat P Ongusaha, Johanna Myllyharju, Dongmei Cheng, Outi Pakkanen, Yujiang Shi, Sam W Lee, Junmin Peng, Yang Shi

  Source: Nature. 2008 Sep 18

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• Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

  Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked …

  Authors: Xiaoyong Yang, Pat P Ongusaha, Philip D Miles, Joyce C Havstad, Fengxue Zhang, W Venus So, Jeffrey E Kudlow, Robert H Michell, Jerrold M Olefsky, Seth J Field,…

  Source: Nature. 2008 Feb 21

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• GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.

  The p53 tumor suppressor protein has a well-established role in cell-fate decision-making processes. However, recent discoveries indicate that p53 has…

  Authors: Takao Ide, Lauren Brown-Endres, Kiki Chu, Pat P Ongusaha, Takao Ohtsuka, Wafik S El-Deiry, Stuart A Aaronson, Sam W Lee

  Source: Molecular cell. 2009 Nov 13

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• Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation.

  Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachmen…

  Authors: Sanjeev Das, Pat P Ongusaha, Yoon Sun Yang, Jin-Mo Park, Stuart A Aaronson, Sam W Lee

  Source: Cancer research. 2006 Aug 15

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• HB-EGF is a potent inducer of tumor growth and angiogenesis.

  Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to stimulate the growth of a variety of cells in an autocrine or pa…

  Authors: Pat P Ongusaha, Jennifer C Kwak, Andrew J Zwible, Salvador Macip, Shigeki Higashiyama, Naoyuki Taniguchi, Li Fang, Sam W Lee

  Source: Cancer research. 2004 Aug 1

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• BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.

  The tumor suppressor protein BRCA1 has been shown to enhance p53 transcription, whereas activated p53 represses BRCA1 transcription. To further unders…

  Authors: Pat P Ongusaha, Toru Ouchi, Kyung-Tae Kim, Emily Nytko, Jennifer C Kwak, Rosemary B Duda, Chu-Xia Deng, Sam W Lee

  Source: Oncogene. 2003 Jun 12

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• The protective role of a small GTPase RhoE against UVB-induced DNA damage in keratinocytes.

  RhoE, a p53 target gene, was identified as a critical factor for the survival of human keratinocytes in response to UVB. The Rho family of GTPases reg…

  Authors: Sarah A Boswell, Pat P Ongusaha, Paul Nghiem, Sam W Lee

  Source: The Journal of biological chemistry. 2007 Feb 16

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• Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.

  Although apoptosis triggered by ultraviolet B (UVB)-mediated activation of the c-Jun N-terminal kinase (JNK) pathway is mediated by both intrinsic and…

  Authors: Pat P Ongusaha, Hank H Qi, Lakshmi Raj, Young-Bum Kim, Stuart A Aaronson, Roger J Davis, Yang Shi, James K Liao, Sam W Lee

  Source: Science signaling. 2008

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• Maximizing tumor cell invasion.

  Authors: Pat P Ongusaha, Sam W Lee

  Source: Pigment cell & melanoma research. 2009 Apr

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• CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

  We have identified a novel pro-apoptotic p53 target gene named CDIP (Cell Death Involved p53-target). Inhibition of CDIP abrogates p53-mediated apopto…

  Authors: Lauren Brown, Pat P Ongusaha, Hyung-Gu Kim, Shanthy Nuti, Anna Mandinova, Ji Won Lee, Roya Khosravi-Far, Stuart A Aaronson, Sam W Lee

  Source: The EMBO journal. 2007 Jul 25

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