1 to 10 of 32 literature results

• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Family-based association study of lithium-related and other candidate genes in bipolar disorder.

  CONTEXT: Association studies in bipolar disorder have been focused on a relatively narrow pool of candidate genes based on a limited understanding of …

  Authors: Roy H Perlis, Shaun Purcell, Jesen Fagerness, Andrew Kirby, Tracey L Petryshen, Jinbo Fan, Pamela Sklar

  Source: Archives of general psychiatry. 2008 Jan

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• Principles of haplotype mapping and potential applications to attention-deficit/hyperactivity disorder.

  Approaches to the study of common, complex genetic disorders like attention-deficit/hyperactivity disorder (ADHD) are evolving rapidly. Traditional li…

  Authors: Pamela Sklar

  Source: Biological psychiatry. 2005 Jun 1

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• Linkage analysis in psychiatric disorders: the emerging picture.

  Gene finding in genetically complex diseases has been difficult as a result of many factors that have diagnostic and methodologic considerations. For …

  Authors: Pamela Sklar

  Source: Annual review of genomics and human genetics. 2002

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.

  DTNBP1 was first identified as a putative schizophrenia-susceptibility gene in Irish pedigrees, with a report of association to common genetic variati…

  Authors: Mousumi Mutsuddi, Derek W Morris, Skye G Waggoner, Mark J Daly, Edward M Scolnick, Pamela Sklar

  Source: American journal of human genetics. 2006 Nov

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• Identification of EFHC2 as a quantitative trait locus for fear recognition in Turner syndrome.

  One-third of women with Turner syndrome (45,X) have autism-like social and communication difficulties, despite normal verbal IQ. Deletion mapping of t…

  Authors: Lauren A Weiss, Shaun Purcell, Skye Waggoner, Kate Lawrence, David Spektor, Mark J Daly, Pamela Sklar, David Skuse

  Source: Human molecular genetics. 2007 Jan 1

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• Assessing the impact of population stratification on genetic association studies.

  Population stratification refers to differences in allele frequencies between cases and controls due to systematic differences in ancestry rather than…

  Authors: Matthew L Freedman, David Reich, Kathryn L Penney, Gavin J McDonald, Andre A Mignault, Nick Patterson, Stacey B Gabriel, Eric J Topol, Jordan W Smoller, Carlos N Pato,…

  Source: Nature genetics. 2004 Apr

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• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools …

  Authors: Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly,…

  Source: American journal of human genetics. 2007 Sep

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