1 to 10 of 102 literature results

• Human T cell responses against melanoma.

  Many antigens recognized by autologous T lymphocytes have been identified on human melanoma. Melanoma patients usually mount a spontaneous T cell resp…

  Authors: Thierry Boon, Pierre G Coulie, Benoît J Van den Eynde, Pierre van der Bruggen

  Source: Annual review of immunology. 2006

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• Processing and presentation of tumor antigens and vaccination strategies.

  Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptide…

  Authors: Pierre van der Bruggen, Benoît J Van den Eynde

  Source: Current opinion in immunology. 2006 Feb

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• Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

  For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their bin…

  Authors: Nathalie Demotte, Vincent Stroobant, Pierre J Courtoy, Patrick Van Der Smissen, Didier Colau, Immanuel F Luescher, Claire Hivroz, Julie Nicaise, Jean-Luc Squifflet, Michel Mourad,…

  Source: Immunity. 2008 Mar

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• The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.

  Melanoma patients were injected with various vaccines containing a MAGE-A3 peptide presented by HLA-DP4. Anti-MAGE-A3.DP4 T cells were not detectable …

  Authors: Violaine François, Sabrina Ottaviani, Nicolina Renkvist, Julie Stockis, Gerold Schuler, Kris Thielemans, Didier Colau, Marie Marchand, Thierry Boon, Sophie Lucas,…

  Source: Cancer research. 2009 May 15

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• T-cell responses of vaccinated cancer patients.

  Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Sev…

  Authors: Pierre G Coulie, Pierre van der Bruggen

  Source: Current opinion in immunology. 2003 Apr

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• CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation.

  The expression of CD45RA on CCR7- human CD8+ memory T cells is widely considered to be a marker of terminal differentiation. We studied the time cours…

  Authors: Javier Carrasco, Danièle Godelaine, Aline Van Pel, Thierry Boon, Pierre van der Bruggen

  Source: Blood. 2006 Nov 1

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• Comparison of stable human Treg and Th clones by transcriptional profiling.

  From cancerous and non-cancerous patients, we derived stable clones of CD4(+) Treg, defined as clones that expressed high CD25 at rest, were anergic i…

  Authors: Julie Stockis, Wolfram Fink, Violaine François, Thierry Connerotte, Charles de Smet, Laurent Knoops, Pierre van der Bruggen, Thierry Boon, Pierre G Coulie, Sophie Lucas

  Source: European journal of immunology. 2009 Mar

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• Efficient presentation of known HLA class II-restricted MAGE-A3 epitopes by dendritic cells electroporated with messenger RNA encoding an invariant chain with genetic exchange of class II-associated invariant chain peptide.

  For the induction of an optimal immune response against cancer or infections not only CD8(+) CTLs but also CD4(+) T helper cells must be induced, in p…

  Authors: Aude Bonehill, Carlo Heirman, Sandra Tuyaerts, Annelies Michiels, Yi Zhang, Pierre van der Bruggen, Kris Thielemans

  Source: Cancer research. 2003 Sep 1

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• CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A.

  Mild/moderate hemophilia A patients carrying certain mutations in the C1 domain of factor VIII (FVIII) have a higher risk of inhibitor occurrence. To …

  Authors: Marc Jacquemin, Valérie Vantomme, Cécile Buhot, Renaud Lavend'homme, Wivine Burny, Nathalie Demotte, Pascal Chaux, Kathelijne Peerlinck, Jos Vermylen, Bernard Maillere,…

  Source: Blood. 2003 Feb 15

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• Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines.

  Until now, studies utilizing mRNA electroporation as a tool for the delivery of tumor antigens to human monocyte-derived dendritic cells (DC) have foc…

  Authors: A Michiels, S Tuyaerts, A Bonehill, J Corthals, K Breckpot, C Heirman, S Van Meirvenne, M Dullaers, S Allard, F Brasseur,…

  Source: Gene therapy. 2005 May

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