1 to 10 of 13 literature results

• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs,…

  Authors: F Penna, P Reffo, G Muzio, R A Canuto, F M Baccino, G Bonelli, P Costelli

  Source: Biochemical pharmacology. 2009 Jan 15

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• Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-alpha.

  Depletion of skeletal muscle protein mainly results from enhanced protein breakdown, caused by activation of proteolytic systems such as the Ca2+-depe…

  Authors: Andrea Bonetto, Fabio Penna, Valerio G Minero, Patrizia Reffo, Domiziana Costamagna, Gabriella Bonelli, Francesco M Baccino, Paola Costelli

  Source: Amino acids. 2010 Jul 10

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• Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody.

  The liver is particularly susceptible to Fas-mediated cytotoxicity. Mice given an adequate parenteral dose of agonistic anti-Fas antibody (aFas) or of…

  Authors: P Costelli, P Aoki, B Zingaro, N Carbó, P Reffo, F J Lopez-Soriano, G Bonelli, J M Argilés, F M Baccino

  Source: Cell death and differentiation. 2003 Sep

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• Muscle myostatin signalling is enhanced in experimental cancer cachexia.

  BACKGROUND/AIMS: Myostatin belongs to the transforming growth factor-beta superfamily and negatively regulates skeletal muscle mass. Its deletion indu…

  Authors: P Costelli, M Muscaritoli, A Bonetto, F Penna, P Reffo, M Bossola, G Bonelli, G B Doglietto, F M Baccino, F Rossi Fanelli

  Source: European journal of clinical investigation. 2008 Jul

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• Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.

  Muscle wasting, as occurring in cancer cachexia, is primarily characterized by protein hypercatabolism and increased expression of ubiquitin ligases, …

  Authors: A Bonetto, F Penna, V G Minero, P Reffo, G Bonelli, F M Baccino, P Costelli

  Source: Current cancer drug targets. 2009 Aug

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• Mechanisms involved in growth inhibition induced by clofibrate in hepatoma cells.

  Low concentrations of some peroxisome proliferators have been found to decrease apoptosis in rat liver cells, whereas higher but pharmacological conce…

  Authors: Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Patrizia Reffo, Sebastiano Colombatto, Rosa Angela Canuto

  Source: Toxicology. 2003 May 3

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• Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.

  Ceramide has been suggested as an important mediator of apoptosis. In HT-29 colorectal cancer cells increased ceramide levels, induced by exogenous N-…

  Authors: Daniela De Stefanis, Patrizia Reffo, Gabriella Bonelli, Francesco M Baccino, Giuseppina Sala, Riccardo Ghidoni, Patrice Codogno, Ciro Isidoro

  Source: Biological chemistry. 2002 Jun

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• Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress.

  Cachexia is a debilitating syndrome characterized by body weight loss, muscle wasting, and anemia. Muscle wasting results from an altered balance betw…

  Authors: Raffaella Mastrocola, Patrizia Reffo, Fabio Penna, Chiara Elena Tomasinelli, Giuseppe Boccuzzi, Francesco Maria Baccino, Manuela Aragno, Paola Costelli

  Source: Free radical biology & medicine. 2008 Feb 15

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• Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy.

  Calcineurin has been proposed to regulate skeletal muscle hypertrophy, while its relevance to the pathogenesis of muscle atrophy is unknown. The prese…

  Authors: Paola Costelli, Vanessa Almendro, Maria Teresa Figueras, Patrizia Reffo, Fabio Penna, Manuela Aragno, Raffaella Mastrocola, Giuseppe Boccuzzi, Silvia Busquets, Gabriella Bonelli,…

  Source: Biochimica et biophysica acta. 2007 Jul

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• Ca(2+)-dependent proteolysis in muscle wasting.

  Skeletal muscle wasting is a prominent feature of cachexia, a complex systemic syndrome that frequently complicates chronic diseases such as inflammat…

  Authors: Paola Costelli, Patrizia Reffo, Fabio Penna, Riccardo Autelli, Gabriella Bonelli, Francesco M Baccino

  Source: The international journal of biochemistry & cell biology. 2005 Oct

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