1 to 10 of 72 literature results

• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs,…

  Authors: F Penna, P Reffo, G Muzio, R A Canuto, F M Baccino, G Bonelli, P Costelli

  Source: Biochemical pharmacology. 2009 Jan 15

  View Full Text

• Proteasome activities in the rectus abdominis muscle of young and older individuals.

  Sarcopenia is one of the most striking effects of age, the causes and the pathogenic mechanisms being largely unknown. Unfortunately, there is limited…

  Authors: Maurizio Bossola, Fabio Pacelli, Paola Costelli, Antonio Tortorelli, Fausto Rosa, Giovan Battista Doglietto

  Source: Biogerontology. 2008 Aug

  View Full Text

• Interleukin-15 increases calcineurin expression in 3T3-L1 cells: possible involvement on in vivo adipocyte differentiation.

  Different studies have revealed that the Ca2+-dependent serine/threonine phosphatase calcineurin is involved in the regulation of adipocyte differenti…

  Authors: Vanessa Almendro, Gemma Fuster, Elisabet Ametller, Paola Costelli, Federica Pilla, Sílvia Busquets, Maite Figueras, Josep M Argilés, Francisco J López-Soriano

  Source: International journal of molecular medicine. 2009 Oct

  View Full Text

• Muscle myostatin signalling is enhanced in experimental cancer cachexia.

  BACKGROUND/AIMS: Myostatin belongs to the transforming growth factor-beta superfamily and negatively regulates skeletal muscle mass. Its deletion indu…

  Authors: P Costelli, M Muscaritoli, A Bonetto, F Penna, P Reffo, M Bossola, G Bonelli, G B Doglietto, F M Baccino, F Rossi Fanelli

  Source: European journal of clinical investigation. 2008 Jul

  View Full Text

• Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody.

  The liver is particularly susceptible to Fas-mediated cytotoxicity. Mice given an adequate parenteral dose of agonistic anti-Fas antibody (aFas) or of…

  Authors: P Costelli, P Aoki, B Zingaro, N Carbó, P Reffo, F J Lopez-Soriano, G Bonelli, J M Argilés, F M Baccino

  Source: Cell death and differentiation. 2003 Sep

  View Full Text

• Mechanisms of skeletal muscle depletion in wasting syndromes: role of ATP-ubiquitin-dependent proteolysis.

  PURPOSE OF REVIEW: Muscle protein wasting frequently complicates patient outcome in several chronic pathologies. The underlying mechanisms remain larg…

  Authors: Paola Costelli, Francesco M Baccino

  Source: Current opinion in clinical nutrition and metabolic care. 2003 Jul

  View Full Text

• Increased muscle proteasome activity correlates with disease severity in gastric cancer patients.

  OBJECTIVE: To investigate the state of activation of the ATP-ubiquitin-dependent proteolytic system in the skeletal muscle of gastric cancer patients.…

  Authors: Maurizio Bossola, Maurizio Muscaritoli, Paola Costelli, Gabriella Grieco, Gabriella Bonelli, Fabio Pacelli, Filippo Rossi Fanelli, Giovanni Battista Doglietto, Francesco Maria Baccino

  Source: Annals of surgery. 2003 Mar

  View Free Full Text

• Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.

  Cachexia is a syndrome characterized by profound tissue wasting that frequently complicates malignancies. In a cancer cachexia model we have shown tha…

  Authors: P Costelli, R D Tullio, F M Baccino, E Melloni

  Source: British journal of cancer. 2001 Apr 6

  View Free Full Text

• Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase.

  Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family. PPs are well-recognized hepatocarcinogens, though only for ro…

  Authors: Rosa A Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M Baccino

  Source: Journal of lipid research. 2003 Jan

  View Full Text

• Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma.

  Overexpression of the proto-oncogene c-ski in mice results in the development of a hypertrophic phenotype, characterized by increases in body and musc…

  Authors: Neus Carbó, Paola Costelli, Sílvia Busquets, Joaquín López-Soriano, Francisco J López-Soriano, Francesco M Baccino, Josep M Argilés

  Source: International journal of molecular medicine. 2004 Oct

  View Full Text