1 to 7 of 7 literature results

• In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.

  Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, inclu…

  Authors: Stefan Nierkens, Martijn H den Brok, Roger P M Sutmuller, Oliver M Grauer, Erik Bennink, Mary E Morgan, Carl G Figdor, Theo J M Ruers, Gosse J Adema

  Source: Cancer research. 2008 Jul 1

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• Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

  The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analys…

  Authors: Joannes F M Jacobs, Albert J Idema, Kalijn F Bol, Stefan Nierkens, Oliver M Grauer, Pieter Wesseling, J André Grotenhuis, Peter M Hoogerbrugge, I Jolanda M de Vries, Gosse J Adema

  Source: Neuro-oncology. 2009 Aug

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• Immunotherapy of diffuse gliomas: biological background, current status and future developments.

  Despite aggressive multimodal treatment approaches, the prognosis for patients with diffuse gliomas remains disappointing. Glioma cells often extensiv…

  Authors: Oliver M Grauer, Pieter Wesseling, Gosse J Adema

  Source: Brain pathology (Zurich, Switzerland). 2009 Oct

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• Selective cancer-germline gene expression in pediatric brain tumors.

  Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expres…

  Authors: Joannes F M Jacobs, Oliver M Grauer, Francis Brasseur, Peter M Hoogerbrugge, Pieter Wesseling, Corrie E Gidding, Mandy W M M van de Rakt, Carl G Figdor, Pierre G Coulie, I Jolanda M de Vries,…

  Source: Journal of neuro-oncology. 2008 Jul

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• TLR ligands in the local treatment of established intracerebral murine gliomas.

  Local TLR stimulation is an attractive approach to induce antitumor immunity. In this study, we compared various TLR ligands for their ability to affe…

  Authors: Oliver M Grauer, Johan W Molling, Erik Bennink, Liza W J Toonen, Roger P M Sutmuller, Stefan Nierkens, Gosse J Adema

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Nov 15

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• Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.

  Both melanoma and glioma cells are of neuroectodermal origin and share common tumor associated antigens. In this article, we report that the melanocyt…

  Authors: Oliver M Grauer, Roger P M Sutmuller, Wendy van Maren, Joannes F M Jacobs, Erik Bennink, Liza W J Toonen, Stefan Nierkens, Gosse J Adema

  Source: International journal of cancer. Journal international du cancer. 2008 Apr 15

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• CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

  The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. …

  Authors: Oliver M Grauer, Stefan Nierkens, Erik Bennink, Liza W J Toonen, Louis Boon, Pieter Wesseling, Roger P M Sutmuller, Gosse J Adema

  Source: International journal of cancer. Journal international du cancer. 2007 Jul 1

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