1 to 10 of 302 literature results

• The kallikrein-kinin system in health and in diseases of the kidney.

  Since kallikrein was discovered as a vasodilatory substance in human urine, the kallikrein-kinin system (KKS) has been considered to play a physiologi…

  Authors: Masao Kakoki, Oliver Smithies

  Source: Kidney international. 2009 May

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• Forty years with homologous recombination.

  Authors: O Smithies

  Source: Nature medicine. 2001 Oct

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• Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

  To study the effects of modestly increased expression of aldosterone synthase (AS), we generated mice (AS(hi/hi)) by replacing the 3' untranslated reg…

  Authors: Natalia Makhanova, John Hagaman, Hyung-Suk Kim, Oliver Smithies

  Source: Hypertension. 2008 Jan

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• Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.

  Renin-synthesizing cells are crucial in the regulation of blood pressure and fluid-electrolyte homeostasis. Adult mammals subjected to manipulations t…

  Authors: Maria Luisa S Sequeira López, Ellen S Pentz, Takayo Nomasa, Oliver Smithies, R Ariel Gomez

  Source: Developmental cell. 2004 May

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• Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene.

  Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. To date, numerous in vitro studies have suggested that AM can…

  Authors: Ryan T Dackor, Kimberly Fritz-Six, William P Dunworth, Carrie L Gibbons, Oliver Smithies, Kathleen M Caron

  Source: Molecular and cellular biology. 2006 Apr

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• Altering the expression in mice of genes by modifying their 3' regions.

  Polymorphic differences altering expression of genes without changing their products probably underlie human quantitative traits affecting risks of se…

  Authors: Masao Kakoki, Yau-Sheng Tsai, Hyung-Suk Kim, Seigo Hatada, Dominic J Ciavatta, Nobuyuki Takahashi, Larry W Arnold, Nobuyo Maeda, Oliver Smithies

  Source: Developmental cell. 2004 Apr

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• Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

  To examine a role for focal adhesion kinase (FAK) in cardiac morphogenesis, we generated a line of mice with a conditional deletion of FAK in nkx2-5-e…

  Authors: Zeenat S Hakim, Laura A DiMichele, Jason T Doherty, Jonathon W Homeister, Hilary E Beggs, Louis F Reichardt, Robert J Schwartz, Joseph Brackhan, Oliver Smithies, Christopher P Mack,…

  Source: Molecular and cellular biology. 2007 Aug

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• Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

  We have determined that differences in expression of aldosterone synthase (AS) affect responses to a low-salt diet. In AS-null mice (AS(-/-)), but not…

  Authors: Natalia Makhanova, Maria L S Sequeira-Lopez, R Ariel Gomez, Hyung-Suk Kim, Oliver Smithies

  Source: Hypertension. 2006 Dec

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• Gender-dependent survival of allogeneic trophoblast stem cells in liver.

  In view of the well-known phenomenon of trophoblast immune privilege, trophoblast stem cells (TSCs) might be expected to be immune-privileged, which c…

  Authors: Jessica Epple-Farmer, Bisrat G Debeb, Oliver Smithies, Bert Binas

  Source: Cell transplantation. 2009 Apr 29

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• Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis.

  The natriuretic peptides, atrial (ANP) and brain natriuretic peptide (BNP) are known to suppress cardiac hypertrophy and fibrosis. Both ANP and BNP ex…

  Authors: Leigh J Ellmers, Nicola J A Scott, Jarkko Piuhola, Nobuyo Maeda, Oliver Smithies, Chris M Frampton, A Mark Richards, Vicky A Cameron

  Source: Journal of molecular endocrinology. 2007 Feb

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