1 to 10 of 50 literature results

• TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

  Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen…

  Authors: Yong-Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui-Hsi Wang, Rene de Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F Ziegler

  Source: Annual review of immunology. 2007

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• Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.

  Hassall's corpuscles-first described in the human thymus over 150 years ago-are groups of epithelial cells within the thymic medulla. The physical nat…

  Authors: Norihiko Watanabe, Yi-Hong Wang, Heung Kyu Lee, Tomoki Ito, Yui-Hsi Wang, Wei Cao, Yong-Jun Liu

  Source: Nature. 2005 Aug 25

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• Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.

  BACKGROUND & AIMS: Because of the lack of animal models developing spontaneous autoimmune hepatitis (AIH), the molecular mechanisms involved in the de…

  Authors: Masahiro Kido, Norihiko Watanabe, Taku Okazaki, Takuji Akamatsu, Junya Tanaka, Kazuyuki Saga, Akiyoshi Nishio, Tasuku Honjo, Tsutomu Chiba

  Source: Gastroenterology. 2008 Oct

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• Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

  T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T cell pool. Although dendritic cells (DCs) seem to be impo…

  Authors: Norihiko Watanabe, Shino Hanabuchi, Vassili Soumelis, Wei Yuan, Stephen Ho, Rene de Waal Malefyt, Yong-Jun Liu

  Source: Nature immunology. 2004 Apr

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• Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.

  The identity of TH2 memory cells and the mechanism regulating their maintenance during allergic inflammation remain elusive. We report that circulated…

  Authors: Yui-Hsi Wang, Tomoki Ito, Yi-Hong Wang, Bernhard Homey, Norihiko Watanabe, Rachel Martin, Christopher J Barnes, Bradley W McIntyre, Michel Gilliet, Rakesh Kumar,…

  Source: Immunity. 2006 Jun

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• Small intestine Peyer's patches are major induction sites of the Helicobacter-induced host immune responses.

  Authors: Norihiko Watanabe, Keiichi Kiriya, Tsutomu Chiba

  Source: Gastroenterology. 2008 Feb

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• BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.

  During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenu…

  Authors: Norihiko Watanabe, Maya Gavrieli, John R Sedy, Jianfei Yang, Francesca Fallarino, Susan K Loftin, Michelle A Hurchla, Natalie Zimmerman, Julia Sim, Xingxing Zang,…

  Source: Nature immunology. 2003 Jul

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• IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.

  RATIONALE: The IL-23-IL-17A-producing CD4(+) T-cell (Th17 cell) axis plays an important role in the development of chronic inflammatory diseases, incl…

  Authors: Hidefumi Wakashin, Koichi Hirose, Yuko Maezawa, Shin-ichiro Kagami, Akira Suto, Norihiko Watanabe, Yasushi Saito, Masahiko Hatano, Takeshi Tokuhisa, Yoichiro Iwakura,…

  Source: American journal of respiratory and critical care medicine. 2008 Nov 15

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• Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.

  It is well documented that dendritic cells (DCs), representative antigen-presenting cells, are important sources of Th1-promoting cytokines and are ac…

  Authors: Naoki Tokumasa, Akira Suto, Shin-Ichiro Kagami, Shunsuke Furuta, Koichi Hirose, Norihiko Watanabe, Yasushi Saito, Kazuya Shimoda, Itsuo Iwamoto, Hiroshi Nakajima

  Source: Blood. 2007 Jul 15

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• Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).

  Plasmacytoid dendritic cell precursors (pDCs) are professional type I interferon-producing cells, a critical cell type in regulating innate and adapti…

  Authors: Shino Hanabuchi, Norihiko Watanabe, Yi-Hong Wang, Yui-Hsi Wang, Tomoki Ito, Joanne Shaw, Wei Cao, F Xiao-Feng Qin, Yong-Jun Liu

  Source: Blood. 2006 May 1

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