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alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet.
Considerable evidence indicates that hyperglycemia increases oxidative stress and contributes to the increased incidence of atherosclerosis and cardio…
Authors: Xianwen Yi, Nobuyo Maeda
Source: Diabetes. 2006 Aug
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Endogenous production of lipoic acid is essential for mouse development.
alpha-Lipoic acid (LA) is a cofactor for mitochondrial alpha-ketoacid dehydrogenase complexes and is one of the most potent, natural antioxidants. Red…
Authors: Xianwen Yi, Nobuyo Maeda
Source: Molecular and cellular biology. 2005 Sep
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Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation.
BACKGROUND: Thiazolidinediones have been reported to protect against ischemia-reperfusion injury. Their protective actions are considered to be peroxi…
Authors: Jui-Sheng Wu, Wai-Mui Cheung, Yau-Sheng Tsai, Yi-Tong Chen, Wen-Hsuan Fong, Hsin-Da Tsai, Yu-Chang Chen, Jun-Yang Liou, Song-Kun Shyue, Jin-Jer Chen,…
Source: Circulation. 2009 Mar 3
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Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid.
BACKGROUND: Oxidative stress is thought to play an important role in atherogenesis, suggesting that antioxidants could prevent coronary artery disease…
Authors: Yukiko Nakata, Nobuyo Maeda
Source: Circulation. 2002 Mar 26
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Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond.
Given the multiple differences between mice and men, it was once thought that mice could not be used to model atherosclerosis, principally a human dis…
Authors: Avani A Pendse, Jose M Arbones-Mainar, Lance A Johnson, Michael K Altenburg, Nobuyo Maeda
Source: Journal of lipid research. 2009 Apr
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Altering the expression in mice of genes by modifying their 3' regions.
Polymorphic differences altering expression of genes without changing their products probably underlie human quantitative traits affecting risks of se…
Authors: Masao Kakoki, Yau-Sheng Tsai, Hyung-Suk Kim, Seigo Hatada, Dominic J Ciavatta, Nobuyuki Takahashi, Larry W Arnold, Nobuyo Maeda, Oliver Smithies
Source: Developmental cell. 2004 Apr
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The role of natriuretic peptides in cardioprotection.
Atrial natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP) are circulating hormones of cardiac origin that play an important role i…
Authors: Toshio Nishikimi, Nobuyo Maeda, Hiroaki Matsuoka
Source: Cardiovascular research. 2006 Feb 1
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Recipes for creating animal models of diabetic cardiovascular disease.
For more than 50 years, investigators have unsuccessfully tried to recreate in experimental animals the cardiovascular complications of diabetes seen …
Authors: Willa Hsueh, E Dale Abel, Jan L Breslow, Nobuyo Maeda, Richard C Davis, Edward A Fisher, Hayes Dansky, Donald A McClain, Richard McIndoe, Momtaz K Wassef,…
Source: Circulation research. 2007 May 25
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Genetics of atherosclerosis in murine models.
The pathology of atherosclerotic lesions that develop in mouse models of atherosclerosis, such as those lacking apolipoprotein E or lacking the low de…
Authors: Michael Altenburg, Jonathon Homeister, Heather Doherty, Nobuyo Maeda
Source: Current drug targets. 2007 Nov
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CIB1 is essential for mouse spermatogenesis.
CIB1 is a 22-kDa calcium binding, regulatory protein with approximately 50% homology to calmodulin and calcineurin B. CIB1 is widely expressed and bin…
Authors: Weiping Yuan, Tina M Leisner, Andrew W McFadden, Shantres Clark, Sylvia Hiller, Nobuyo Maeda, Deborah A O'Brien, Leslie V Parise
Source: Molecular and cellular biology. 2006 Nov
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