1 to 10 of 37 literature results

• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

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• Strong evidence that GNB1L is associated with schizophrenia.

  Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schiz…

  Authors: Nigel M Williams, Beate Glaser, Nadine Norton, Hywel Williams, Timothy Pierce, Valentina Moskvina, Stephen Monks, Jurgen Del Favero, Dirk Goossens, Dan Rujescu,…

  Source: Human molecular genetics. 2008 Feb 15

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• Analysis of copy number variation using quantitative interspecies competitive PCR.

  Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, …

  Authors: Nigel M Williams, Hywel Williams, Elisa Majounie, Nadine Norton, Beate Glaser, Huw R Morris, Michael J Owen, Michael C O'Donovan

  Source: Nucleic acids research. 2008 Oct

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• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

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• A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

  The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine me…

  Authors: Nicholas J Bray, Paul R Buckland, Nigel M Williams, Hywel J Williams, Nadine Norton, Michael J Owen, Michael C O'Donovan

  Source: American journal of human genetics. 2003 Jul

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• Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1.

  Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expr…

  Authors: Nicholas J Bray, Peter A Holmans, Marianne B van den Bree, Lesley Jones, Lyn A Elliston, Gareth Hughes, Alexander L Richards, Nigel M Williams, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2008 Apr 15

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• Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia.

  CONTEXT: Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been repor…

  Authors: Timothy R Peirce, Nicholas J Bray, Nigel M Williams, Nadine Norton, Valentina Moskvina, Anna Preece, Vahram Haroutunian, Joseph D Buxbaum, Michael J Owen, Michael C O'Donovan

  Source: Archives of general psychiatry. 2006 Jan

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• Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia.

  BACKGROUND: There is support that Neuregulin 1 (NRG1) plays a role in susceptibility to schizophrenia but limited evidence for its involvement in bipo…

  Authors: Lyudmila Georgieva, Albena Dimitrova, Dobril Ivanov, Ivan Nikolov, Nigel M Williams, Detelina Grozeva, Irina Zaharieva, Draga Toncheva, Michael J Owen, George Kirov,…

  Source: Biological psychiatry. 2008 Sep 1

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• Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression.

  The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia. However, the confidence with which thi…

  Authors: Nicholas J Bray, Anna Preece, Nigel M Williams, Valentina Moskvina, Paul R Buckland, Michael J Owen, Michael C O'Donovan

  Source: Human molecular genetics. 2005 Jul 15

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• The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study.

  BACKGROUND: An increasing number of dominant and recessive disorders have been associated with late onset chronic progressive ataxia (LOCA) complicati…

  Authors: Mark Wardle, Elisa Majounie, Mustapha B Muzaimi, Nigel M Williams, Huw R Morris, Neil P Robertson

  Source: Journal of neurology. 2009 Mar

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