1 to 10 of 77 literature results

• Diagnosis of functional psychoses: time to face the future.

  Authors: Michael J Owen, Nick Craddock

  Source: Lancet. 2009 Jan 17

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Microduplications of 16p11.2 are associated with schizophrenia.

  Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental …

  Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…

  Source: Nature genetics. 2009 Nov

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

  It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on c…

  Authors: Sarah Cohen-Woods, Daria Gaysina, Nick Craddock, Anne Farmer, Joanna Gray, Cerisse Gunasinghe, Farzana Hoda, Lisa Jones, Jo Knight, Ania Korszun,…

  Source: Human molecular genetics. 2009 Apr 15

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• Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1.

  Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expr…

  Authors: Nicholas J Bray, Peter A Holmans, Marianne B van den Bree, Lesley Jones, Lyn A Elliston, Gareth Hughes, Alexander L Richards, Nigel M Williams, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2008 Apr 15

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• A longitudinal study of hypomania and depression symptoms in pregnancy and the postpartum period.

  OBJECTIVES: Childbirth is a potent precipitant of severe episodes of bipolar disorder. We investigate mood longitudinally through pregnancy and the po…

  Authors: Jessica Heron, Sayeed Haque, Femi Oyebode, Nick Craddock, Ian Jones

  Source: Bipolar disorders. 2009 Jun

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• Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses.

  As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specif…

  Authors: Nick Craddock, M C O'Donovan, M J Owen

  Source: Schizophrenia bulletin. 2009 May

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• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

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