1 to 10 of 21 literature results

• Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells.

  Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids …

  Authors: Nathan L Alderson, Hiroko Hama

  Source: Journal of lipid research. 2009 Jun

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• Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

  Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), w…

  Authors: Vidyullatha Vasireddy, Yoshikazu Uchida, Norman Salem, Soo Yeon Kim, Md Nawajesh Ali Mandal, Geereddy Bhanuprakash Reddy, Ravi Bodepudi, Nathan L Alderson, Johnie C Brown, Hiroko Hama,…

  Source: Human molecular genetics. 2007 Mar 1

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• FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin.

  Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acid…

  Authors: Eduardo N Maldonado, Nathan L Alderson, Paula V Monje, Patrick M Wood, Hiroko Hama

  Source: Journal of lipid research. 2008 Jan

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• A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry.

  Fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is an enzyme responsible for the de novo synthesis of sphingolipids containing 2-hydroxy fa…

  Authors: Nathan L Alderson, Michael D Walla, Hiroko Hama

  Source: Journal of lipid research. 2005 Jul

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• FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain.

  2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydrox…

  Authors: Nathan L Alderson, Eduardo N Maldonado, Michael J Kern, Narayan R Bhat, Hiroko Hama

  Source: Journal of lipid research. 2006 Dec

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• Chemical modification of proteins during peroxidation of phospholipids.

  Chemical modification of proteins by advanced glycation and lipoxidation end products is implicated in the pathogenesis of macrovascular disease in ag…

  Authors: Andrzej S Januszewski, Nathan L Alderson, Alicia J Jenkins, Suzanne R Thorpe, John W Baynes

  Source: Journal of lipid research. 2005 Jul

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• Definition of the immunogenic forms of modified human LDL recognized by human autoantibodies and by rabbit hyperimmune antibodies.

  Humans and laboratory animals recognize human modified LDL as immunogenic. Immune complexes (ICs) isolated from human sera contain malondialdehyde-mod…

  Authors: Gabriel Virella, Suzanne R Thorpe, Nathan L Alderson, M Brooks Derrick, Charlyne Chassereau, J Matthew Rhett, Maria F Lopes-Virella

  Source: Journal of lipid research. 2004 Oct

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• The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats.

  BACKGROUND: In previous studies, pyridoxamine (PM) limited the formation of advanced glycation end products (AGEs) and development of nephropathy in s…

  Authors: Nathan L Alderson, Mark E Chachich, Nancy N Youssef, Robert J Beattie, Maurice Nachtigal, Suzanne R Thorpe, John W Baynes

  Source: Kidney international. 2003 Jun

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• The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

  We examined the ability of pyridoxamine (PM), an inhibitor of formation of advanced glycation end products (AGEs) and lipoxidation end products (ALEs)…

  Authors: Alan Stitt, Thomas A Gardiner, Nathan L Alderson, Paul Canning, Norma Frizzell, Noel Duffy, Cliona Boyle, Andrzej S Januszewski, Mark Chachich, John W Baynes,…

  Source: Diabetes. 2002 Sep

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• Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.

  BACKGROUND: Nonenzymatic reactions between sugars or lipids and protein and formation of advanced glycation and lipoxidation end products (AGE/ALEs) c…

  Authors: Thorsten P Degenhardt, Nathan L Alderson, David D Arrington, Robert J Beattie, John M Basgen, Michael W Steffes, Suzanne R Thorpe, John W Baynes

  Source: Kidney international. 2002 Mar

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