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Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop f…
Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…
Source: Nature medicine. 2009 Aug
View Full TextThe transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epi…
Authors: Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees,…
Source: Nature cell biology. 2007 Feb
View Full TextThe cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models…
Authors: François Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader
Source: Cancer research. 2008 Oct 1
View Full TextThe estrogen receptor alpha (ERalpha), progesterone receptor (PR), and erbB2 (Her2 in humans) are important prognostic markers of human breast cancer,…
Authors: Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, François Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman
Source: Journal of the National Cancer Institute. 2006 Jul 19
View Full TextSuppressor of cytokine signalling (SOCS) proteins are critical attenuators of cytokine-mediated signalling in diverse tissues. To determine the import…
Authors: Kate D Sutherland, François Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh,…
Source: The EMBO journal. 2006 Dec 13
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