1 to 10 of 25 literature results

• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

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• Prediction of individual genetic risk of complex disease.

  Most common diseases are caused by multiple genetic and environmental factors. In the last 2 years, genome-wide association studies (GWAS) have identi…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Current opinion in genetics & development. 2008 Jun

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• Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk.

  The current paradigm within genetic diagnostics is to test individuals only at loci known to affect risk of complex disease-yet the technology exists …

  Authors: David M Evans, Peter M Visscher, Naomi R Wray

  Source: Human molecular genetics. 2009 Sep 15

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• Prediction of individual genetic risk to disease from genome-wide association studies.

  Empirical studies suggest that the effect sizes of individual causal risk alleles underlying complex genetic diseases are small, with most genotype re…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Genome research. 2007 Oct

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• Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.

  CONTEXT: People meeting diagnostic criteria for anxiety or depressive disorders tend to score high on the personality scale of neuroticism. Studying t…

  Authors: Naomi R Wray, Christel M Middeldorp, Andrew J Birley, Scott D Gordon, Patrick F Sullivan, Peter M Visscher, Dale R Nyholt, Gonneke Willemsen, Eco J C de Geus, P Eline Slagboom,…

  Source: Archives of general psychiatry. 2008 Jun

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• Anxiety and comorbid measures associated with PLXNA2.

  CONTEXT: Reduction in adult neurogenesis has been proposed as a mechanism for onset of depression. Semaphorins and their coreceptors, plexins, have be…

  Authors: Naomi R Wray, Michael R James, Steven P Mah, Matthew Nelson, Gavin Andrews, Patrick F Sullivan, Grant W Montgomery, Andrew J Birley, Andreas Braun, Nicholas G Martin

  Source: Archives of general psychiatry. 2007 Mar

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• Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures.

  BACKGROUND: The length polymorphism repeat in the promoter region of the serotonin transporter gene (5HTTLPR) is one of the most studied polymorphisms…

  Authors: Naomi R Wray, Michael R James, Scott D Gordon, Troy Dumenil, Leanne Ryan, William L Coventry, Dixie J Statham, Michele L Pergadia, Pamela A F Madden, Andrew C Heath,…

  Source: Biological psychiatry. 2009 Sep 1

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• Shared temperament risk factors for anorexia nervosa: a twin study.

  OBJECTIVE: To answer two questions about the nature of the relationship between anorexia nervosa (AN) and dimensional temperament traits: Which traits…

  Authors: Tracey D Wade, Marika Tiggemann, Cynthia M Bulik, Christopher G Fairburn, Naomi R Wray, Nicholas G Martin

  Source: Psychosomatic medicine. 2008 Feb

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• Conventional multipoint nonparametric linkage analysis is not necessarily inherently biased.

  Authors: Peter M Visscher, Naomi R Wray

  Source: American journal of human genetics. 2004 Oct

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• Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin study.

  BACKGROUND: Major depression (MD) and anxiety disorders such as panic disorder (PD), agoraphobia (AG), and social phobia (SP) are heritable and highly…

  Authors: Miriam A Mosing, Scott D Gordon, Sarah E Medland, Dixie J Statham, Elliot C Nelson, Andrew C Heath, Nicholas G Martin, Naomi R Wray

  Source: Depression and anxiety. 2009

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