1 to 10 of 42 literature results

• Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.

  Bone morphogenetic proteins (BMP) are members of the transforming growth factor-beta superfamily, and they play an important role for embryonic develo…

  Authors: Hong Jin Lee, Yan Ji, Shiby Paul, Hubert Maehr, Milan Uskokovic, Nanjoo Suh

  Source: Cancer research. 2007 Dec 15

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• Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation.

  Calcitriol is implicated in many cellular functions including cellular growth and differentiation, thus explaining its antitumor effects. It was shown…

  Authors: Hubert Maehr, Hong Jin Lee, Bradford Perry, Nanjoo Suh, Milan R Uskokovic

  Source: Journal of medicinal chemistry. 2009 Sep 10

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• Cancer Preventive Activities of Tocopherols and Tocotrienols.

  The cancer preventive activity of vitamin E has been studied. Whereas some epidemiological studies have suggested a protective effect of vitamin E aga…

  Authors: Jihyeung Ju, Sonia C Picinich, Zhihong Yang, Yang Zhao, Nanjoo Suh, Ah-Ng Kong, Chung S Yang

  Source: Carcinogenesis. 2009 Sep 11

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• Dietary intake of pterostilbene, a constituent of blueberries, inhibits the {beta}-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats.

  Stilbenes are phytochemicals present in grapes, berries, peanuts and red wine. A widely studied stilbene, resveratrol (trans-3,5,4'-trihydroxystilbene…

  Authors: Shiby Paul, Andrew Decastro, Hong Jin Lee, Amanda K Smolarek, Jae Young So, Barbara Simi, Chung Xiou Wang, Renping Zhou, Agnes M Rimando, Nanjoo Suh

  Source: Carcinogenesis. 2010 Jan 8

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• Biological/chemopreventive activity of stilbenes and their effect on colon cancer.

  Colon cancer is one of the leading causes of cancer death in men and women in Western countries. Epidemiological studies have linked the consumption o…

  Authors: Agnes M Rimando, Nanjoo Suh

  Source: Planta medica. 2008 Oct

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• CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.

  2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces differentiation and apoptosis of tumor cells in vitro and in vivo. Here we assessed the e…

  Authors: Steffen Koschmieder, Francesco D'Alò, Hanna Radomska, Christine Schöneich, Ji Suk Chang, Marina Konopleva, Susumu Kobayashi, Elena Levantini, Nanjoo Suh, Annalisa Di Ruscio,…

  Source: Blood. 2007 Nov 15

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• Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

  Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has been shown to induce apoptosis specifically in cancer cells while sparing…

  Authors: Marc L Hyer, Rhonda Croxton, Maryla Krajewska, Stanislaw Krajewski, Christina L Kress, Meiling Lu, Nanjoo Suh, Michael B Sporn, Vincent L Cryns, Juan M Zapata,…

  Source: Cancer research. 2005 Jun 1

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• Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives.

  Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activi…

  Authors: Jungil Hong, Shengmin Sang, Hye-Jin Park, Seok Joo Kwon, Nanjoo Suh, Mou-Tuan Huang, Chi-Tang Ho, Chung S Yang

  Source: Carcinogenesis. 2006 Feb

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• The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.

  The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO) induces apoptosis in leukemic cells. Here we show that CDDO and its …

  Authors: Dharminder Chauhan, Guilan Li, Klaus Podar, Teru Hideshima, Reshma Shringarpure, Laurence Catley, Constantine Mitsiades, Nikhil Munshi, Yu Tzu Tai, Nanjoo Suh,…

  Source: Blood. 2004 Apr 15

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• A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells.

  We investigated the action of 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], a novel Gemini vitamin D(3) analog Ro-438-3582 [1alpha,25-dihydr…

  Authors: Hong Jin Lee, Andrew Wislocki, Catherine Goodman, Yan Ji, Rongrong Ge, Hubert Maehr, Milan Uskokovic, Michael Reiss, Nanjoo Suh

  Source: Molecular pharmacology. 2006 Jun

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