1 to 10 of 225 literature results

• Vertebrate membrane proteins: structure, function, and insights from biophysical approaches.

  Membrane proteins are key targets for pharmacological intervention because they are vital for cellular function. Here, we analyze recent progress made…

  Authors: Daniel J Müller, Nan Wu, Krzysztof Palczewski

  Source: Pharmacological reviews. 2008 Mar

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• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.

  Intracellular heme levels must be tightly regulated to maintain proper mitochondrial respiration while minimizing toxicity, but the homeostatic mechan…

  Authors: Nan Wu, Lei Yin, Elyisha A Hanniman, Shree Joshi, Mitchell A Lazar

  Source: Genes & development. 2009 Sep 15

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• Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.

  Although the BCR/ABL tyrosine kinase inhibitor imatinib is highly effective for treatment of chronic myelogenous leukemia and Philadelphia chromosome-…

  Authors: Tetsuya Kurosu, Manabu Ohki, Nan Wu, Hiroyuki Kagechika, Osamu Miura

  Source: Cancer research. 2009 May 1

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• Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells.

  1,3-Bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) is reported to be an activator of human ether-à-go-go-related gene current. However, it rem…

  Authors: Sheng-Nan Wu, Hsung Peng, Bing-Shuo Chen, Ya-Jean Wang, Pei-Yu Wu, Ming-Wei Lin

  Source: Molecular pharmacology. 2008 Dec

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• Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells.

  The effects of rottlerin, a known inhibitor of protein kinase C-delta activation, on ion currents were investigated in pituitary tumor (GH3) cells. Ro…

  Authors: Sheng-Nan Wu, Ya-Jean Wang, Ming-Wei Lin

  Source: Journal of cellular physiology. 2007 Mar

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• Histone H2A has a novel variant in fish oocytes.

  Histone variants and their modification have significant roles in many cellular processes. In this study, we identified and characterized the histone …

  Authors: Nan Wu, Hua-Mei Yue, Bo Chen, Jian-Fang Gui

  Source: Biology of reproduction. 2009 Aug

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• Optical pressure/acoustic sensor with precise Fabry-Perot cavity length control using angle polished fiber.

  This paper presents a novel Fabry-Perot (FP) optical fiber pressure/acoustic sensor. It consists of two V-shaped grooves having different sized widths…

  Authors: Wenhui Wang, Nan Wu, Ye Tian, Xingwei Wang, Christopher Niezrecki, Julie Chen

  Source: Optics express. 2009 Sep 14

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• Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein.

  The helicase domain of dengue virus NS3 protein (DENV NS3H) contains RNA-stimulated nucleoside triphosphatase (NTPase), ATPase/helicase, and RNA 5'-tr…

  Authors: Chun-Chung Wang, Zhi-Shun Huang, Pei-Ling Chiang, Chien-Tsun Chen, Huey-Nan Wu

  Source: FEBS letters. 2009 Feb 18

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• Experimental and theoretical electron density study of estrone.

  The electron density and the electrostatic potential (ESP) distributions of estrone have been determined using X-ray diffraction analysis and compared…

  Authors: Elizabeth A Zhurova, Chérif F Matta, Nan Wu, Vladimir V Zhurov, A Alan Pinkerton

  Source: Journal of the American Chemical Society. 2006 Jul 12

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• Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA-binding mode.

  PriB is a primosomal protein required for replication restart in Escherichia coli. PriB stimulates PriA helicase activity via interaction with single-…

  Authors: Cheng-Yang Huang, Che-Hsiung Hsu, Yuh-Ju Sun, Huey-Nan Wu, Chwan-Deng Hsiao

  Source: Nucleic acids research. 2006

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