1 to 10 of 91 literature results

• MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors.

  B7-H3, a surface immunomodulatory glycoprotein, inhibits natural killer cells and T cells. The monoclonal antibody (mAb) 8H9 is specific for 4Ig-B7-H3…

  Authors: Hong Xu, Irene Y Cheung, Hong-Fen Guo, Nai-Kong V Cheung

  Source: Cancer research. 2009 Aug 1

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• Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.

  We prospectively observed a child exposed to intensive multimodality therapy for metastatic neuroblastoma from emergence of a MLL translocation to dis…

  Authors: Blaine W Robinson, Nai-Kong V Cheung, Christos P Kolaris, Suresh C Jhanwar, John K Choi, Neil Osheroff, Carolyn A Felix

  Source: Blood. 2008 Apr 1

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• Neuroblastoma: Therapeutic strategies for a clinical enigma.

  Neuroblastoma, the most common extracranial pediatric solid tumor remains a clinical enigma with outcomes ranging from cure in >90% of patients with l…

  Authors: Shakeel Modak, Nai-Kong V Cheung

  Source: Cancer treatment reviews. 2010 Jun

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• Monoclonal antibody therapies for solid tumors.

  BACKGROUND: About 1.4 million new cancer cases are expected to be diagnosed in the US in 2008 and the overall costs of cancer treatment is estimated a…

  Authors: Dimiter V Tassev, Nai-Kong V Cheung

  Source: Expert opinion on biological therapy. 2009 Mar

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• Differential impact of high-dose cyclophosphamide, topotecan, and vincristine in clinical subsets of patients with chemoresistant neuroblastoma.

  BACKGROUND: In what to the authors' knowledge is the first such study for a pediatric cancer, a large database was retrospectively analyzed to assess …

  Authors: Brian H Kushner, Kim Kramer, Shakeel Modak, Li-Xuan Qin, Nai-Kong V Cheung

  Source: Cancer. 2010 Jun 15

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• Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma.

  BACKGROUND: Neuroblastoma is the most common extracranial solid malignancy in infancy and childhood, but the biological factors involved in its develo…

  Authors: Miguel Alaminos, Veronica Davalos, Nai-Kong V Cheung, William L Gerald, Manel Esteller

  Source: Journal of the National Cancer Institute. 2004 Aug 18

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• Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer.

  The role of complement in antibody therapy of cancer is in general poorly understood. We used the EL4 syngeneic mouse model of metastatic lymphoma to …

  Authors: Masaki Imai, Charles Landen, Rieko Ohta, Nai-Kong V Cheung, Stephen Tomlinson

  Source: Cancer research. 2005 Nov 15

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• Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity.

  Ganglioside GD2 is a cell surface glycosphingolipid. Targeting of GD2, i.e., by anti-GD2 mAb 3F8, is used clinically for cancer diagnosis, prognosis, …

  Authors: Wenyong Tong, Martin Gagnon, Tara Sprules, Michel Gilbert, Shafinaz Chowdhury, Karen Meerovitch, Karl Hansford, Enrico O Purisima, John W Blankenship, Nai-Kong V Cheung,…

  Source: Chemistry & biology. 2010 Feb 26

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• In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma.

  The 8H9 monoclonal antibody (MAb) is highly reactive with a cell surface glycoprotein expressed on human breast cancers, childhood sarcomas, and neuro…

  Authors: Masanori Onda, Qing-cheng Wang, Hong-fen Guo, Nai-Kong V Cheung, Ira Pastan

  Source: Cancer research. 2004 Feb 15

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• Measuring circulating neuroblastoma cells by quantitative reverse transcriptase-polymerase chain reaction analysis.

  BACKGROUND: Histologic examination of bone marrow (BM) is an accepted clinical standard for the detection of metastatic neuroblastoma (NB). Circulatin…

  Authors: Irene Y Cheung, Arvind Sahota, Nai-Kong V Cheung

  Source: Cancer. 2004 Nov 15

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