1 to 10 of 39 literature results

• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

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• Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.

  CONTEXT: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. OBJECTIVE: To investigate whether …

  Authors: Gary Donohoe, James Walters, Derek W Morris, Emma M Quinn, Róisín Judge, Nadine Norton, Ina Giegling, Annette M Hartmann, Hans-Jürgen Möller, Pierandrea Muglia,…

  Source: Archives of general psychiatry. 2009 Oct

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• Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.

  Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorde…

  Authors: George Kirov, Dilihan Gumus, Wei Chen, Nadine Norton, Lyudmila Georgieva, Murat Sari, Michael C O'Donovan, Fikret Erdogan, Michael J Owen, Hans-Hilger Ropers,…

  Source: Human molecular genetics. 2008 Feb 1

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• Analysis of copy number variation using quantitative interspecies competitive PCR.

  Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, …

  Authors: Nigel M Williams, Hywel Williams, Elisa Majounie, Nadine Norton, Beate Glaser, Huw R Morris, Michael J Owen, Michael C O'Donovan

  Source: Nucleic acids research. 2008 Oct

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• Strong evidence that GNB1L is associated with schizophrenia.

  Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schiz…

  Authors: Nigel M Williams, Beate Glaser, Nadine Norton, Hywel Williams, Timothy Pierce, Valentina Moskvina, Stephen Monks, Jurgen Del Favero, Dirk Goossens, Dan Rujescu,…

  Source: Human molecular genetics. 2008 Feb 15

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• Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia.

  CONTEXT: Convergent data make 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) a candidate gene for schizophrenia. Reduced expression has been repor…

  Authors: Timothy R Peirce, Nicholas J Bray, Nigel M Williams, Nadine Norton, Valentina Moskvina, Anna Preece, Vahram Haroutunian, Joseph D Buxbaum, Michael J Owen, Michael C O'Donovan

  Source: Archives of general psychiatry. 2006 Jan

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• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

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• HTR2A: association and expression studies in neuropsychiatric genetics.

  Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuro…

  Authors: Nadine Norton, Michael J Owen

  Source: Annals of medicine. 2005

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• A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

  The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine me…

  Authors: Nicholas J Bray, Paul R Buckland, Nigel M Williams, Hywel J Williams, Nadine Norton, Michael J Owen, Michael C O'Donovan

  Source: American journal of human genetics. 2003 Jul

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