1 to 9 of 9 literature results

• A survey of genetic human cortical gene expression.

  It is widely assumed that genetic differences in gene expression underpin much of the difference among individuals and many of the quantitative traits…

  Authors: Amanda J Myers, J Raphael Gibbs, Jennifer A Webster, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem, Doris Leung, Leslie Bryden, Priti Nath,…

  Source: Nature genetics. 2007 Dec

  View Full Text

• Genetic control of human brain transcript expression in Alzheimer disease.

  We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. W…

  Authors: Jennifer A Webster, J Raphael Gibbs, Jennifer Clarke, Monika Ray, Weixiong Zhang, Peter Holmans, Kristen Rohrer, Alice Zhao, Lauren Marlowe, Mona Kaleem,…

  Source: American journal of human genetics. 2009 Apr

  View Free Full Text

• GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.

  The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome…

  Authors: Eric M Reiman, Jennifer A Webster, Amanda J Myers, John Hardy, Travis Dunckley, Victoria L Zismann, Keta D Joshipura, John V Pearson, Diane Hu-Lince, Matthew J Huentelman,…

  Source: Neuron. 2007 Jun 7

  View Free Full Text

• A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

  Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one …

  Authors: Andrew Grupe, Yonghong Li, Charles Rowland, Petra Nowotny, Anthony L Hinrichs, Scott Smemo, John S K Kauwe, Taylor J Maxwell, Sara Cherny, Lisa Doil,…

  Source: American journal of human genetics. 2006 Jan

  View Free Full Text

• Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.

  Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affect…

  Authors: Scott Smemo, Petra Nowotny, Anthony L Hinrichs, John S K Kauwe, Sara Cherny, Katherine Erickson, Amanda J Myers, Mona Kaleem, Lauren Marlowe, Alison M Gibson,…

  Source: Annals of neurology. 2006 Jan

  View Full Text

• The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts.

  Previously we have shown that the H1c haplotype on the background of the H1 clade of haplotypes at the MAPT locus is associated with increased risk fo…

  Authors: Amanda J Myers, Alan M Pittman, Alice S Zhao, Kristen Rohrer, Mona Kaleem, Lauren Marlowe, Andrew Lees, Doris Leung, Ian G McKeith, Robert H Perry,…

  Source: Neurobiology of disease. 2007 Mar

  View Full Text

• Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.

  Mutations in the DJ-1 gene are associated with recessive, early onset Parkinson's disease (PD). We reported previously that one of the point mutations…

  Authors: Jeff Blackinton, Rili Ahmad, David W Miller, Marcel P van der Brug, Rosa M Canet-Avilés, Stephen M Hague, Mona Kaleem, Mark R Cookson

  Source: Brain research. Molecular brain research. 2005 Mar 24

  View Full Text

• Sorl1 as an Alzheimer's disease predisposition gene?

  Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive …

  Authors: Jennifer A Webster, Amanda J Myers, John V Pearson, David W Craig, Diane Hu-Lince, Keith D Coon, Victoria L Zismann, Thomas Beach, Doris Leung, Leslie Bryden,…

  Source: Neuro-degenerative diseases. 2008

  View Full Text

• A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

  OBJECTIVE: While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome …

  Authors: Keith D Coon, Amanda J Myers, David W Craig, Jennifer A Webster, John V Pearson, Diane Hu Lince, Victoria L Zismann, Thomas G Beach, Doris Leung, Leslie Bryden,…

  Source: The Journal of clinical psychiatry. 2007 Apr

  View Full Text