1 to 10 of 39 literature results

• IL-17 and Th17 Cells.

  CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector funct…

  Authors: Thomas Korn, Estelle Bettelli, Mohamed Oukka, Vijay K Kuchroo

  Source: Annual review of immunology. 2009

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• Induction and effector functions of T(H)17 cells.

  T helper (T(H)) cells constitute an important arm of the adaptive immune system because they coordinate defence against specific pathogens, and their …

  Authors: Estelle Bettelli, Thomas Korn, Mohamed Oukka, Vijay K Kuchroo

  Source: Nature. 2008 Jun 19

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• T(H)-17 cells in the circle of immunity and autoimmunity.

  CD4(+) effector T cells have been categorized into two subsets: T helper type 1 (T(H)1) and T(H)2. Another subset of T cells that produce interleukin …

  Authors: Estelle Bettelli, Mohamed Oukka, Vijay K Kuchroo

  Source: Nature immunology. 2007 Apr

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• IL-21 and TGF-beta are required for differentiation of human T(H)17 cells.

  The recent discovery of CD4(+) T cells characterized by secretion of interleukin (IL)-17 (T(H)17 cells) and the naturally occurring regulatory FOXP3(+…

  Authors: Li Yang, David E Anderson, Clare Baecher-Allan, William D Hastings, Estelle Bettelli, Mohamed Oukka, Vijay K Kuchroo, David A Hafler

  Source: Nature. 2008 Jul 17

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• IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.

  On activation, naive T cells differentiate into effector T-cell subsets with specific cytokine phenotypes and specialized effector functions. Recently…

  Authors: Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B Strom, Mohamed Oukka, Vijay K Kuchroo

  Source: Nature. 2007 Jul 26

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• Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.

  Regulatory T cells (T(reg)) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of T(r…

  Authors: Francisco J Quintana, Alexandre S Basso, Antonio H Iglesias, Thomas Korn, Mauricio F Farez, Estelle Bettelli, Mario Caccamo, Mohamed Oukka, Howard L Weiner

  Source: Nature. 2008 May 1

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• A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

  Regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinc…

  Authors: Amit Awasthi, Yijun Carrier, Jean P S Peron, Estelle Bettelli, Masahito Kamanaka, Richard A Flavell, Vijay K Kuchroo, Mohamed Oukka, Howard L Weiner

  Source: Nature immunology. 2007 Dec

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• Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

  On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are tra…

  Authors: Estelle Bettelli, Yijun Carrier, Wenda Gao, Thomas Korn, Terry B Strom, Mohamed Oukka, Howard L Weiner, Vijay K Kuchroo

  Source: Nature. 2006 May 11

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• IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

  Transcription factor Foxp3 is critical for generating regulatory T cells (T(reg) cells). Transforming growth factor-beta (TGF-beta) induces Foxp3 and …

  Authors: Valérie Dardalhon, Amit Awasthi, Hyoung Kwon, George Galileos, Wenda Gao, Raymond A Sobel, Meike Mitsdoerffer, Terry B Strom, Wassim Elyaman, I-Cheng Ho,…

  Source: Nature immunology. 2008 Dec

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• Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

  Treatment with ex vivo-generated regulatory T cells (T-reg) has been regarded as a potentially attractive therapeutic approach for autoimmune diseases…

  Authors: Thomas Korn, Jayagopala Reddy, Wenda Gao, Estelle Bettelli, Amit Awasthi, Troels R Petersen, B Thomas Bäckström, Raymond A Sobel, Kai W Wucherpfennig, Terry B Strom,…

  Source: Nature medicine. 2007 Apr

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