1 to 10 of 62 literature results

• Epigenetic transcriptional repression of cellular genes by a viral SET protein.

  Viruses recruit host proteins to secure viral genome maintenance and replication. However, whether they modify host histones directly to interfere wit…

  Authors: Shiraz Mujtaba, Karishma L Manzur, James R Gurnon, Ming Kang, James L Van Etten, Ming-Ming Zhou

  Source: Nature cell biology. 2008 Sep

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• Epigenetic transcriptional repression of cellular genes by a viral SET protein.

  Viruses recruit host proteins to secure viral genome maintenance and replication. However, whether they modify host histones directly to interfere wit…

  Authors: Shiraz Mujtaba, Karishma L Manzur, James R Gurnon, Ming Kang, James L Van Etten, Ming-Ming Zhou

  Source: Nature cell biology. 2008 Aug 17

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• Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.

  Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression…

  Authors: Bo Huang, Xiao-Dong Yang, Ming-Ming Zhou, Keiko Ozato, Lin-Feng Chen

  Source: Molecular and cellular biology. 2009 Mar

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• Structure and conserved RNA binding of the PAZ domain.

  The discovery of RNA-mediated gene-silencing pathways, including RNA interference, highlights a fundamental role of short RNAs in eukaryotic gene regu…

  Authors: Kelley S Yan, Sherry Yan, Amjad Farooq, Arnold Han, Lei Zeng, Ming-Ming Zhou

  Source: Nature. 2003 Nov 27

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• PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

  Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind …

  Authors: Alexey V Ivanov, Hongzhuang Peng, Vyacheslav Yurchenko, Kyoko L Yap, Dmitri G Negorev, David C Schultz, Elyse Psulkowski, William J Fredericks, David E White, Gerd G Maul,…

  Source: Molecular cell. 2007 Dec 14

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• Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.

  Epigenetic gene silencing in eukaryotes is regulated in part by lysine methylation of the core histone proteins. While histone lysine methylation is k…

  Authors: Srihari C Sampath, Ivan Marazzi, Kyoko L Yap, Srinath C Sampath, Andrew N Krutchinsky, Ingrid Mecklenbräuker, Agnes Viale, Eugene Rudensky, Ming-Ming Zhou, Brian T Chait,…

  Source: Molecular cell. 2007 Aug 17

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• Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.

  The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members of the Polycomb group (PcG) of transcriptional re…

  Authors: Marta Barradas, Emma Anderton, Juan Carlos Acosta, Side Li, Ana Banito, Marc Rodriguez-Niedenführ, Goedele Maertens, Michaela Banck, Ming-Ming Zhou, Martin J Walsh,…

  Source: Genes & development. 2009 May 15

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• The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor.

  MMSET, identified by its fusion to the IgH locus in t(4;14)-associated multiple myeloma, possesses domains found within chromatin regulators, includin…

  Authors: Jotin Marango, Manabu Shimoyama, Hitomi Nishio, Julia A Meyer, Dong-Joon Min, Andres Sirulnik, Yolanda Martinez-Martinez, Marta Chesi, P Leif Bergsagel, Ming-Ming Zhou,…

  Source: Blood. 2008 Mar 15

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• Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.

  Lysine acetylation of the tumor suppressor protein p53 in response to a wide variety of cellular stress signals is required for its activation as a tr…

  Authors: Shiraz Mujtaba, Yan He, Lei Zeng, Sherry Yan, Olga Plotnikova, Sachchidanand, Roberto Sanchez, Nancy J Zeleznik-Le, Ze'ev Ronai, Ming-Ming Zhou

  Source: Molecular cell. 2004 Jan 30

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• Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.

  Endothelin-converting enzyme-2 (ECE-2), a member of M13 family of zinc metallopeptidases, has previously been shown to process a number of neuropeptid…

  Authors: Khatuna Gagnidze, Sachchidanand, Raphael Rozenfeld, Mihaly Mezei, Ming-Ming Zhou, Lakshmi A Devi

  Source: Journal of medicinal chemistry. 2008 Jun 26

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