1 to 10 of 36 literature results

• Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis.

  Accumulation of toxic metabolites in hereditary tyrosinemia type I (HT1) patients leads to chronic DNA damage and the highest risk for hepatocellular …

  Authors: Holger Willenbring, Amar Deep Sharma, Arndt Vogel, Andrew Y Lee, Andreas Rothfuss, Zhongya Wang, Milton Finegold, Markus Grompe

  Source: Cancer cell. 2008 Jul 8

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• Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice.

  Mice that could be highly repopulated with human hepatocytes would have many potential uses in drug development and research applications. The best av…

  Authors: Hisaya Azuma, Nicole Paulk, Aarati Ranade, Craig Dorrell, Muhsen Al-Dhalimy, Ewa Ellis, Stephen Strom, Mark A Kay, Milton Finegold, Markus Grompe

  Source: Nature biotechnology. 2007 Aug

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• Myelomonocytic cells are sufficient for therapeutic cell fusion in liver.

  Liver repopulation with bone marrow-derived hepatocytes (BMHs) can cure the genetic liver disease fumarylacetoacetate hydrolase (Fah) deficiency. BMHs…

  Authors: Holger Willenbring, Alexis S Bailey, Mark Foster, Yassmine Akkari, Craig Dorrell, Susan Olson, Milton Finegold, William H Fleming, Markus Grompe

  Source: Nature medicine. 2004 Jul

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• Cell fusion is the principal source of bone-marrow-derived hepatocytes.

  Evidence suggests that haematopoietic stem cells might have unexpected developmental plasticity, highlighting therapeutic potential. For example, bone…

  Authors: Xin Wang, Holger Willenbring, Yassmine Akkari, Yumi Torimaru, Mark Foster, Muhsen Al-Dhalimy, Eric Lagasse, Milton Finegold, Susan Olson, Markus Grompe

  Source: Nature. 2003 Apr 24

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• Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.

  Fanconi anemia (FA) is a genetic disorder characterized by congenital abnormalities, bone marrow failure, and marked cancer susceptibility. FA patient…

  Authors: Qing-Shuo Zhang, Laura Eaton, Eric R Snyder, Scott Houghtaling, James B Mitchell, Milton Finegold, Carter Van Waes, Markus Grompe

  Source: Cancer research. 2008 Mar 1

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• Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.

  BACKGROUND & AIMS: Increased rates of apoptosis have been reported to play a role in the pathophysiology of many disorders, including liver diseases. …

  Authors: Arndt Vogel, Joseph E Aslan, Holger Willenbring, Christian Klein, Milton Finegold, Howard Mount, Gary Thomas, Markus Grompe

  Source: Gastroenterology. 2006 Jan

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• Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.

  Fanconi anemia (FA) is an autosomal recessive disease characterized by progressive bone marrow failure and an increased susceptibility to cancer. FA i…

  Authors: Scott Houghtaling, Laura Granville, Yassmine Akkari, Yumi Torimaru, Susan Olson, Milton Finegold, Markus Grompe

  Source: Cancer research. 2005 Jan 1

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• FOXG1 is overexpressed in hepatoblastoma.

  Bacterial artificial chromosome array comparative genomic hybridization analysis of hepatoblastomas reveals a deletion in the 14q12 locus in 12 of 16 …

  Authors: Adekunle Michael Adesina, Yummy Nguyen, Preethi Guanaratne, Joseph Pulliam, Dolores Lopez-Terrada, Judy Margolin, Milton Finegold

  Source: Human pathology. 2007 Mar

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• Cyclin F disruption compromises placental development and affects normal cell cycle execution.

  Human cyclin F was originally isolated as a cDNA capable of suppressing the temperature sensitivity of a Saccharomyces cerevisiae cdc4-1 mutant. Its t…

  Authors: Michael T Tetzlaff, Chang Bai, Milton Finegold, John Wilson, J Wade Harper, Kathleen A Mahon, Stephen J Elledge

  Source: Molecular and cellular biology. 2004 Mar

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• Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

  Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease severely affecting liver and kidney and is caused by a deficiency in fumarylacet…

  Authors: Chantale Langlois, Rossana Jorquera, Milton Finegold, Albert L Shroads, Peter W Stacpoole, Robert M Tanguay

  Source: Biochemical pharmacology. 2006 May 28

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