1 to 10 of 20 literature results

• Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.

  Bone morphogenetic proteins (BMP) are members of the transforming growth factor-beta superfamily, and they play an important role for embryonic develo…

  Authors: Hong Jin Lee, Yan Ji, Shiby Paul, Hubert Maehr, Milan Uskokovic, Nanjoo Suh

  Source: Cancer research. 2007 Dec 15

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• Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.

  1alpha,25(OH)(2)-16-ene-20-cyclopropyl-vitamin D(3) (13) is several fold more potent than the natural hormone 1alpha,25-dihydroxyvitamin D(3) (1) as a…

  Authors: Gilles Laverny, Giuseppe Penna, Milan Uskokovic, Stanislaw Marczak, Hubert Maehr, Pawel Jankowski, Caroline Ceailles, Paul Vouros, Brenden Smith, Matthew Robinson,…

  Source: Journal of medicinal chemistry. 2009 Apr 23

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• A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells.

  We investigated the action of 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], a novel Gemini vitamin D(3) analog Ro-438-3582 [1alpha,25-dihydr…

  Authors: Hong Jin Lee, Andrew Wislocki, Catherine Goodman, Yan Ji, Rongrong Ge, Hubert Maehr, Milan Uskokovic, Michael Reiss, Nanjoo Suh

  Source: Molecular pharmacology. 2006 Jun

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• A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice.

  Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, dominated by interleukin-12 (IL-12)-depend…

  Authors: Silvia Gregori, Nadia Giarratana, Simona Smiroldo, Milan Uskokovic, Luciano Adorini

  Source: Diabetes. 2002 May

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• The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells.

  Synthetic triterpenoids, CDDO (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) or CDDO-imidazolide [2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid imida…

  Authors: Yan Ji, Hong Jin Lee, Catherine Goodman, Milan Uskokovic, Karen Liby, Michael Sporn, Nanjoo Suh

  Source: Molecular cancer therapeutics. 2006 Jun

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• Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.

  We investigated gene expression changes induced by a novel Gemini Vitamin D(3) analog, RO-438-3582 (1alpha,25-dihydroxy-20S-21(3-hydroxy-3-methyl-buty…

  Authors: Hong Jin Lee, Hao Liu, Catherine Goodman, Yan Ji, Hubert Maehr, Milan Uskokovic, Daniel Notterman, Michael Reiss, Nanjoo Suh

  Source: Biochemical pharmacology. 2006 Jul 28

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• Cellular and molecular events associated with the bone-protecting activity of the noncalcemic vitamin D analog Ro-26-9228 in osteopenic rats.

  We have examined several analogs of 1alpha,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] in an animal model of osteoporosis (ovariectomized rats) to ide…

  Authors: Sara Peleg, Milan Uskokovic, Ago Ahene, Brian Vickery, Zafrira Avnur

  Source: Endocrinology. 2002 May

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• Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases.

  Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] induces DCs with a tolerogenic…

  Authors: Luciano Adorini, Giuseppe Penna, Nadia Giarratana, Milan Uskokovic

  Source: Journal of cellular biochemistry. 2003 Feb 1

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• Vitamin D3 analogs stimulate hair growth in nude mice.

  The active form of vitamin D3 can regulate epidermal keratinization by inducing terminal differentiation; and mice lacking the vitamin D receptor disp…

  Authors: Vijaya Vegesna, James O'Kelly, Milan Uskokovic, Jonathan Said, Nathan Lemp, Takayuki Saitoh, Takayuki Ikezoe, Lise Binderup, H Phillip Koeffler

  Source: Endocrinology. 2002 Nov

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• Ability of potent vitamin D3 analogs to inhibit growth of prostate cancer cells in vivo.

  BACKGROUND: Studies have identified analogs of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], which in vitro are 10- to 3,000-fold more active than 1,25(OH)2…

  Authors: Vijaya Vegesna, James O'Kelly, Jonathan Said, Milan Uskokovic, Lise Binderup, H Phillip Koeffle

  Source: Anticancer research. 2003 Jan-Feb

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