10 literature results

• Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.

  Integrins are the major adhesion receptors of leukocytes and platelets. Beta1 and beta2 integrin function on leukocytes is crucial for a successful im…

  Authors: Lena Svensson, Kimberley Howarth, Alison McDowall, Irene Patzak, Rachel Evans, Siegfried Ussar, Markus Moser, Ayse Metin, Mike Fried, Ian Tomlinson,…

  Source: Nature medicine. 2009 Mar

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• A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.

  Ras family GTPases (RFGs) are known to share many regulatory and effector proteins. How signaling and biological specificity is achieved is poorly und…

  Authors: Pablo Rodriguez-Viciana, Juan Oses-Prieto, Alma Burlingame, Mike Fried, Frank McCormick

  Source: Molecular cell. 2006 Apr 21

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• Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes.

  The Ink4a/Arf locus encodes two distinct proteins, both of which may contribute to senescence and tumor suppression. We find that human diploid fibrob…

  Authors: Sarah Drayton, Janice Rowe, Rebecca Jones, Radost Vatcheva, Darren Cuthbert-Heavens, John Marshall, Mike Fried, Gordon Peters

  Source: Cancer cell. 2003 Oct

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• Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.

  The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are …

  Authors: Thomas J Huot, Janice Rowe, Mark Harland, Sarah Drayton, Sharon Brookes, Chandra Gooptu, Patricia Purkis, Mike Fried, Veronique Bataille, Eiji Hara,…

  Source: Molecular and cellular biology. 2002 Dec

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• HIV-infected patients: the risks of surgery.

  There are increasing demands for surgical interventions in Human Immunodeficiency Virus (HIV)-infected patients as a consequence of antiretroviral the…

  Authors: Lisa Nelson, Mike Fried, Kenneth Stewart

  Source: Journal of perioperative practice. 2009 Jan

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• The risks of surgery in HIV-infected patients.

  There are increasing demands for surgical interventions in Human Immunodeficiency Virus (HIV)-infected patients as a consequence of antiretroviral the…

  Authors: Lisa Nelson, Mike Fried, Kenneth Stewart

  Source: Journal of perioperative practice. 2007 Oct

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• Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control.

  Binding of Src family kinases to membrane-associated polyoma virus middle T-antigen (PyMT) can result in the phosphorylation of PyMT tyrosine 250, whi…

  Authors: Pablo Rodriguez-Viciana, Crista Collins, Mike Fried

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 19

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• The rat ARF protein is translated from two closely spaced ATG start codons and can transcriptionally activate p53 in the absence of p53 protein stabilization.

  We have analyzed the transcriptional start sites of the rat ARF gene and the amino acid sequence of the rat ARF tumor suppressor protein. The 5' end o…

  Authors: Abigail E Hunt, Madeleine G Moule, Mike Fried

  Source: Cell cycle (Georgetown, Tex.). 2006 Jun

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• Modulation of the ARF-p53 pathway by the small DNA tumor viruses.

  The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replic…

  Authors: Clodagh C O'Shea, Mike Fried

  Source: Cell cycle (Georgetown, Tex.). 2005 Mar

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• Role for PP2A in ARF signaling to p53.

  Activation of the ARF-p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF-p53 path…

  Authors: Madeleine G Moule, Crista H Collins, Frank McCormick, Mike Fried

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Sep 28

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