1 to 10 of 18 literature results

• Function, regulation and therapeutic properties of beta-secretase (BACE1).

  beta-Secretase (beta-site amyloid precursor protein cleaving enzyme 1; BACE1) has been identified as the rate limiting enzyme for amyloid-beta-peptide…

  Authors: Michael Willem, Sven Lammich, Christian Haass

  Source: Seminars in cell & developmental biology. 2009 Apr

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• Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.

  Both the dystrophin-glycoprotein complex and alpha7beta1 integrin have critical roles in the maintenance of muscle integrity via the provision of mech…

  Authors: Chun Guo, Michael Willem, Alexander Werner, Gennadij Raivich, Michael Emerson, Ludwig Neyses, Ulrike Mayer

  Source: Human molecular genetics. 2006 Mar 15

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• Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice.

  Force transmission at the myotendinous junction requires a strong link between the muscle cytoskeleton and the extracellular matrix. At the adult junc…

  Authors: Ralph Nawrotzki, Michael Willem, Nicolai Miosge, Heinrich Brinkmeier, Ulrike Mayer

  Source: Human molecular genetics. 2003 Mar 1

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• Basement membrane-dependent survival of retinal ganglion cells.

  PURPOSE: The present study investigates the role of the inner limiting membrane (ILM) in the survival of ganglion cells (GCs) in embryonic chick and m…

  Authors: Willi Halfter, Michael Willem, Ulrike Mayer

  Source: Investigative ophthalmology & visual science. 2005 Mar

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• Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.

  Consecutive cleavages of amyloid precursor protein (APP) generate APP intracellular domain (AICD). Its cellular function is still unclear. In this stu…

  Authors: Runa Hamid, Ellen Kilger, Michael Willem, Neville Vassallo, Markus Kostka, Carsten Bornhövd, Andreas S Reichert, Hans A Kretzschmar, Christian Haass, Jochen Herms

  Source: Journal of neurochemistry. 2007 Aug

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• A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

  Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most promising therapeutic strateg…

  Authors: Andrea Geling, Harald Steiner, Michael Willem, Laure Bally-Cuif, Christian Haass

  Source: EMBO reports. 2002 Jul

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• A non-amyloidogenic function of BACE-2 in the secretory pathway.

  beta-Site amyloid precursor protein cleavage enzyme (BACE)-1 and BACE-2 are members of a novel family of membrane-bound aspartyl proteases. While BACE…

  Authors: Regina Fluhrer, Anja Capell, Gil Westmeyer, Michael Willem, Bianka Hartung, Margaret M Condron, David B Teplow, Christian Haass, Jochen Walter

  Source: Journal of neurochemistry. 2002 Jun

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• Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.

  Alzheimer's disease is characterized by brain deposition of extracellular amyloid beta-peptide (Abeta)-containing plaques. The cellular site of gamma-…

  Authors: Christoph Kaether, Stephanie Schmitt, Michael Willem, Christian Haass

  Source: Traffic (Copenhagen, Denmark). 2006 Apr

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• Macrocyclic statine-based inhibitors of BACE-1.

  Minimal sequence requirements for binding of substrate-derived statine peptides to the aspartyl enzyme were established on the basis of the X-ray cocr…

  Authors: Alessandra Barazza, Marion Götz, Sergio A Cadamuro, Peter Goettig, Michael Willem, Holger Steuber, Tanja Kohler, Anja Jestel, Peter Reinemer, Christian Renner,…

  Source: Chembiochem : a European journal of chemical biology. 2007 Nov 23

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• Control of peripheral nerve myelination by the beta-secretase BACE1.

  Although BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is essential for the generation of amyloid-b peptide in Alzheimer's disease, it…

  Authors: Michael Willem, Alistair N Garratt, Bozidar Novak, Martin Citron, Steve Kaufmann, Andrea Rittger, Bart DeStrooper, Paul Saftig, Carmen Birchmeier, Christian Haass

  Source: Science (New York, N.Y.). 2006 Oct 27

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