1 to 10 of 25 literature results

• Mechanical modes of 'amoeboid' cell migration.

  The morphological term 'amoeboid' migration subsumes a number of rather distinct biophysical modes of cellular locomotion that range from blebbing mot…

  Authors: Tim Lämmermann, Michael Sixt

  Source: Current opinion in cell biology. 2009 Oct

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• Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.

  Integrin activation is essential for the function of all blood cells, including platelets and leukocytes. The blood cell-specific FERM domain protein …

  Authors: Markus Moser, Martina Bauer, Stephan Schmid, Raphael Ruppert, Sarah Schmidt, Michael Sixt, Hao-Ven Wang, Markus Sperandio, Reinhard Fässler

  Source: Nature medicine. 2009 Mar

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• Rapid leukocyte migration by integrin-independent flowing and squeezing.

  All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extr…

  Authors: Tim Lämmermann, Bernhard L Bader, Susan J Monkley, Tim Worbs, Roland Wedlich-Söldner, Karin Hirsch, Markus Keller, Reinhold Förster, David R Critchley, Reinhard Fässler,…

  Source: Nature. 2008 May 1

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• Adaptive force transmission in amoeboid cell migration.

  The leading front of a cell can either protrude as an actin-free membrane bleb that is inflated by actomyosin-driven contractile forces, or as an acti…

  Authors: Jörg Renkawitz, Kathrin Schumann, Michele Weber, Tim Lämmermann, Holger Pflicke, Matthieu Piel, Julien Polleux, Joachim P Spatz, Michael Sixt

  Source: Nature cell biology. 2009 Nov 15

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• Beta1 integrins: zip codes and signaling relay for blood cells.

  At least eight of the twelve known members of the beta1 integrin family are expressed on hematopoietic cells. Among these, the VCAM-1 receptor alpha4b…

  Authors: Michael Sixt, Martina Bauer, Tim Lämmermann, Reinhard Fässler

  Source: Current opinion in cell biology. 2006 Oct

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• Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.

  Lymphocyte motility in lymph nodes is regulated by chemokines, but the contribution of integrins to this motility remains obscure. Here we examined ly…

  Authors: Eilon Woolf, Irina Grigorova, Adi Sagiv, Valentin Grabovsky, Sara W Feigelson, Ziv Shulman, Tanja Hartmann, Michael Sixt, Jason G Cyster, Ronen Alon

  Source: Nature immunology. 2007 Oct

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• Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration.

  Mature dendritic cells (DCs) moving from the skin to the lymph node are a prototypic example of rapidly migrating amoeboid leukocytes. Interstitial DC…

  Authors: Tim Lämmermann, Jörg Renkawitz, Xunwei Wu, Karin Hirsch, Cord Brakebusch, Michael Sixt

  Source: Blood. 2009 Jun 4

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• The microanatomy of T-cell responses.

  The priming of a T cell results from its physical interaction with a dendritic cell (DC) that presents the cognate antigenic peptide. The success rate…

  Authors: Tim Lämmermann, Michael Sixt

  Source: Immunological reviews. 2008 Feb

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• A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.

  The mammalian actin-binding protein 1 (mAbp1, Hip-55, SH3P7) is phosphorylated by the nonreceptor tyrosine kinase Syk that has a fundamental effect fo…

  Authors: Jürgen Schymeinsky, Ronald Gerstl, Ingrid Mannigel, Katy Niedung, David Frommhold, Klaus Panthel, Jürgen Heesemann, Michael Sixt, Thomas Quast, Waldemar Kolanus,…

  Source: Blood. 2009 Nov 5

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• Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

  Adhesion and motility of mammalian leukocytes are essential requirements for innate and adaptive immune defense mechanisms. We show here that the guan…

  Authors: Thomas Quast, Barbara Tappertzhofen, Cora Schild, Jessica Grell, Niklas Czeloth, Reinhold Förster, Ronen Alon, Line Fraemohs, Katrin Dreck, Christian Weber,…

  Source: Blood. 2009 Jun 4

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