1 to 10 of 27 literature results

• Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

  Genome-wide association studies have shown that variation in MTNR1B (melatonin receptor 1B) is associated with insulin and glucose concentrations. Her…

  Authors: Valeriya Lyssenko, Cecilia L F Nagorny, Michael R Erdos, Nils Wierup, Anna Jonsson, Peter Spégel, Marco Bugliani, Richa Saxena, Malin Fex, Nicolo Pulizzi,…

  Source: Nature genetics. 2009 Jan

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• Variants in MTNR1B influence fasting glucose levels.

  To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-…

  Authors: Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, Gudmar Thorleifsson, Ruth J F Loos, Alisa K Manning, Anne U Jackson, Yurii Aulchenko,…

  Source: Nature genetics. 2009 Jan

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• Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

  Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a m…

  Authors: Richa Saxena, Marie-France Hivert, Claudia Langenberg, Toshiko Tanaka, James S Pankow, Peter Vollenweider, Valeriya Lyssenko, Nabila Bouatia-Naji, Josée Dupuis, Anne U Jackson,…

  Source: Nature genetics. 2010 Feb

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• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

  Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabet…

  Authors: Eleftheria Zeggini, Laura J Scott, Richa Saxena, Benjamin F Voight, Jonathan L Marchini, Tianle Hu, Paul I W de Bakker, Gonçalo R Abecasis, Peter Almgren, Gitte Andersen,…

  Source: Nature genetics. 2008 May

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• Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease.

  Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disorder characterized by striking progeroid features. Clinical findings in the sk…

  Authors: Hanna Sagelius, Ylva Rosengardten, Mubashir Hanif, Michael R Erdos, Björn Rozell, Francis S Collins, Maria Eriksson

  Source: Journal of cell science. 2008 Apr 1

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• Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.

  Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by features reminiscent of marked premature ageing. Here, we pres…

  Authors: Maria Eriksson, W Ted Brown, Leslie B Gordon, Michael W Glynn, Joel Singer, Laura Scott, Michael R Erdos, Christiane M Robbins, Tracy Y Moses, Peter Berglund,…

  Source: Nature. 2003 May 15

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• Tissue-specific alternative splicing of TCF7L2.

  Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D…

  Authors: Ludmila Prokunina-Olsson, Cullan Welch, Ola Hansson, Neeta Adhikari, Laura J Scott, Nicolle Usher, Maurine Tong, Andrew Sprau, Amy Swift, Lori L Bonnycastle,…

  Source: Human molecular genetics. 2009 Oct 15

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• Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

  Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, w…

  Authors: Cristen J Willer, Elizabeth K Speliotes, Ruth J F Loos, Shengxu Li, Cecilia M Lindgren, Iris M Heid, Sonja I Berndt, Amanda L Elliott, Anne U Jackson, Claudia Lamina,…

  Source: Nature genetics. 2009 Jan

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• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

  Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide as…

  Authors: Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Anna L Gloyn,…

  Source: Nature genetics. 2010 Feb

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• Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.

  Prior reports have suggested that variants in the genes for maturity-onset diabetes of the young (MODY) may confer susceptibility to type 2 diabetes, …

  Authors: Lori L Bonnycastle, Cristen J Willer, Karen N Conneely, Anne U Jackson, Cecily P Burrill, Richard M Watanabe, Peter S Chines, Narisu Narisu, Laura J Scott, Sareena T Enloe,…

  Source: Diabetes. 2006 Sep

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