1 to 10 of 26 literature results

• The 'short' history of regulatory B cells.

  The maintenance of tolerance is the sine qua non of a sophisticated regulatory apparatus to prevent or dampen overzealous immune responses. In additio…

  Authors: Claudia Mauri, Michael R Ehrenstein

  Source: Trends in immunology. 2008 Jan

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• CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.

  The immunosuppressive function of regulatory B cells has been shown in several murine models of chronic inflammation, including collagen-induced arthr…

  Authors: Paul A Blair, Lina Yassin Noreña, Fabian Flores-Borja, David J Rawlings, David A Isenberg, Michael R Ehrenstein, Claudia Mauri

  Source: Immunity. 2010 Jan 29

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• Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density lipoprotein (LDL) and apoptotic cells and have been implic…

  Authors: Myles J Lewis, Talat H Malik, Michael R Ehrenstein, Joseph J Boyle, Marina Botto, Dorian O Haskard

  Source: Circulation. 2009 Aug 4

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• Cells of the synovium in rheumatoid arthritis. B cells.

  There is significant evidence arising from experimental models that autoantibodies play a key role in the pathogenesis of inflammatory arthritis. In a…

  Authors: Claudia Mauri, Michael R Ehrenstein

  Source: Arthritis research & therapy. 2007

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• Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus.

  CTLA-4 is a critical gatekeeper of T-cell activation and immunological tolerance and has been implicated in patients with a variety of autoimmune dise…

  Authors: Elizabeth C Jury, Fabian Flores-Borja, Hardeep S Kalsi, Mark Lazarus, David A Isenberg, Claudia Mauri, Michael R Ehrenstein

  Source: European journal of immunology. 2010 Feb

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• Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis.

  OBJECTIVE: To study the quantitative and phenotypic reconstitution of peripheral blood B cells and its relationship to the dynamics of clinical respon…

  Authors: Maria J Leandro, Geraldine Cambridge, Michael R Ehrenstein, Jonathan C W Edwards

  Source: Arthritis and rheumatism. 2006 Feb

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• Restoring the balance: harnessing regulatory T cells for therapy in rheumatoid arthritis.

  Treg play a vital role in the maintenance of tolerance to self antigens, thereby preventing disease through the active suppression of proliferation an…

  Authors: Fabian Flores-Borja, Claudia Mauri, Michael R Ehrenstein

  Source: European journal of immunology. 2008 Apr

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• Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro.

  Soluble molecules including complement components have been shown to facilitate the clearance of dying cells by phagocytes, a process that is importan…

  Authors: Pierre Quartier, Paul K Potter, Michael R Ehrenstein, Mark J Walport, Marina Botto

  Source: European journal of immunology. 2005 Jan

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• An open study of B lymphocyte depletion in systemic lupus erythematosus.

  OBJECTIVE: To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion therapy in refractory systemic lupus erythematosus (SLE)…

  Authors: Maria J Leandro, Jonathan C Edwards, Geraldine Cambridge, Michael R Ehrenstein, David A Isenberg

  Source: Arthritis and rheumatism. 2002 Oct

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• Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis.

  OBJECTIVE: To explore the changes in serologic variables and clinical disease activity following B lymphocyte depletion in 22 patients with rheumatoid…

  Authors: Geraldine Cambridge, Maria J Leandro, Jonathan C W Edwards, Michael R Ehrenstein, Martin Salden, Mark Bodman-Smith, Anthony D B Webster

  Source: Arthritis and rheumatism. 2003 Aug

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