1 to 10 of 216 literature results

• Schizophrenia genetics: advancing on two fronts.

  Recent studies have supported the hypothesis that the high heritability of schizophrenia reflects a combination of relatively common alleles of small …

  Authors: Michael J Owen, Hywel J Williams, Michael C O'Donovan

  Source: Current opinion in genetics & development. 2009 Jun

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• Genes for schizophrenia? Recent findings and their pathophysiological implications.

  CONTEXT: Schizophrenia is highly heritable, but the genes have remained elusive. Identifying the genes is essential if the pathogenesis and pathophysi…

  Authors: Paul J Harrison, Michael J Owen

  Source: Lancet. 2003 Feb 1

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• Diagnosis of functional psychoses: time to face the future.

  Authors: Michael J Owen, Nick Craddock

  Source: Lancet. 2009 Jan 17

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• Phenotypic variations on the theme of CNVs.

  Authors: Michael C O'Donovan, George Kirov, Michael J Owen

  Source: Nature genetics. 2008 Dec

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• Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease.

  Hyperekplexia is a human neurological disorder characterized by an excessive startle response and is typically caused by missense and nonsense mutatio…

  Authors: Mark I Rees, Kirsten Harvey, Brian R Pearce, Seo-Kyung Chung, Ian C Duguid, Philip Thomas, Sarah Beatty, Gail E Graham, Linlea Armstrong, Rita Shiang,…

  Source: Nature genetics. 2006 Jul

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• Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo.

  Notch receptors and their ligands contribute to many developmental systems, but it is not apparent how they function after birth, as their null mutant…

  Authors: Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu, Michael J Owen

  Source: Nature immunology. 2004 Jun

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• Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.

  We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wi…

  Authors: Peter Holmans, Elaine K Green, Jaspreet Singh Pahwa, Manuel A R Ferreira, Shaun M Purcell, Pamela Sklar, Wellcome Trust Case-Control Consortium, Michael J Owen, Michael C O'Donovan, Nick Craddock

  Source: American journal of human genetics. 2009 Jul

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).

  Molecular genetic investigations of attention deficit hyperactivity disorder (ADHD) have found associations with a variable number of tandem repeat (V…

  Authors: Dawei Li, Pak C Sham, Michael J Owen, Lin He

  Source: Human molecular genetics. 2006 Jul 15

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• The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.

  Although T cell receptor (TCR)gammadelta+ and TCRalphabeta+ cells are commonly viewed as functionally independent, their relatedness and potential int…

  Authors: Daniel J Pennington, Bruno Silva-Santos, John Shires, Efstathios Theodoridis, Christopher Pollitt, Emma L Wise, Robert E Tigelaar, Michael J Owen, Adrian C Hayday

  Source: Nature immunology. 2003 Oct

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