1 to 10 of 98 literature results

• Molecular physiology of pituitary development: signaling and transcriptional networks.

  The pituitary gland is a central endocrine organ regulating basic physiological functions, including growth, the stress response, reproduction, metabo…

  Authors: Xiaoyan Zhu, Anatoli S Gleiberman, Michael G Rosenfeld

  Source: Physiological reviews. 2007 Jul

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• Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

  Life and death fate decisions allow cells to avoid massive apoptotic death in response to genotoxic stress. Although the regulatory mechanisms and sig…

  Authors: Peter J Cook, Bong Gun Ju, Francesca Telese, Xiangting Wang, Christopher K Glass, Michael G Rosenfeld

  Source: Nature. 2009 Apr 2

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• The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.

  Consistent with the role of microRNAs (miRNAs) in down-regulating gene expression by reducing the translation and/or stability of target messenger RNA…

  Authors: Michele Trabucchi, Paola Briata, Mariaflor Garcia-Mayoral, Astrid D Haase, Witold Filipowicz, Andres Ramos, Roberto Gherzi, Michael G Rosenfeld

  Source: Nature. 2009 Jun 18

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• Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer.

  Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By estab…

  Authors: Chunru Lin, Liuqing Yang, Bogdan Tanasa, Kasey Hutt, Bong-gun Ju, Kenny Ohgi, Jie Zhang, David W Rose, Xiang-Dong Fu, Christopher K Glass,…

  Source: Cell. 2009 Dec 11

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• No rest for REST: REST/NRSF regulation of neurogenesis.

  Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repre…

  Authors: Victoria V Lunyak, Michael G Rosenfeld

  Source: Cell. 2005 May 20

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• A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death.

  Nurr1, an orphan nuclear receptor, plays an essential role in the generation and maintenance of dopaminergic neurons in the brain. Rare mutations in N…

  Authors: Kaoru Saijo, Beate Winner, Christian T Carson, Jana G Collier, Leah Boyer, Michael G Rosenfeld, Fred H Gage, Christopher K Glass

  Source: Cell. 2009 Apr 3

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• Signaling and epigenetic regulation of pituitary development.

  The developing pituitary gland provides an instructive model system for elucidating the molecular mechanisms by which distinct cell types arise from a…

  Authors: Xiaoyan Zhu, Jianxun Wang, Bong-Gun Ju, Michael G Rosenfeld

  Source: Current opinion in cell biology. 2007 Dec

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• Nuclear organization in the 3D space of the nucleus - cause or consequence?

  Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, w…

  Authors: Esperanza Nunez, Xiang-Dong Fu, Michael G Rosenfeld

  Source: Current opinion in genetics & development. 2009 Oct

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• Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.

  Activation of toll-like receptors (TLRs) leads to derepression and subsequent activation of inflammatory response genes that play essential roles in i…

  Authors: Wendy Huang, Serena Ghisletti, Valentina Perissi, Michael G Rosenfeld, Christopher K Glass

  Source: Molecular cell. 2009 Jul 10

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• SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

  A series of transcription factors critical for maintenance of the neural stem cell state have been identified, but the role of functionally important …

  Authors: Kristen Jepsen, Derek Solum, Tianyuan Zhou, Robert J McEvilly, Hyun-Jung Kim, Christopher K Glass, Ola Hermanson, Michael G Rosenfeld

  Source: Nature. 2007 Nov 15

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