1 to 10 of 15 literature results

• The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples.

  The interleukin-11 receptor alpha (IL-11Ralpha) is a functional target in bone metastasis. However, its role in primary bone tumors has not been estab…

  Authors: Valerae O Lewis, Michael G Ozawa, Michael T Deavers, Guiying Wang, Tomo Shintani, Wadih Arap, Renata Pasqualini

  Source: Cancer research. 2009 Mar 1

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• A hybrid vector for ligand-directed tumor targeting and molecular imaging.

  Merging tumor targeting and molecular-genetic imaging into an integrated platform is limited by lack of strategies to enable systemic yet ligand-direc…

  Authors: Amin Hajitou, Martin Trepel, Caroline E Lilley, Suren Soghomonyan, Mian M Alauddin, Frank C Marini, Bradley H Restel, Michael G Ozawa, Catherine A Moya, Roberto Rangel,…

  Source: Cell. 2006 Apr 21

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• The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.

  For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial …

  Authors: Diana E Jaalouk, Michael G Ozawa, Jessica Sun, Johanna Lahdenranta, Reinier O Schlingemann, Renata Pasqualini, Wadih Arap

  Source: Cancer research. 2007 Oct 15

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• Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels.

  Tumor blood vessels normalized by antiangiogenic therapy may provide improved delivery of chemotherapeutic agents during a window of time but it is un…

  Authors: Virginia J Yao, Michael G Ozawa, Amanda S Varner, Ian M Kasman, Yvan H Chanthery, Renata Pasqualini, Wadih Arap, Donald M McDonald

  Source: Cancer research. 2006 Mar 1

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• Aminopeptidase A is a functional target in angiogenic blood vessels.

  We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain…

  Authors: Serena Marchiò, Johanna Lahdenranta, Reinier O Schlingemann, Donatella Valdembri, Pieter Wesseling, Marco A Arap, Amin Hajitou, Michael G Ozawa, Martin Trepel, Ricardo J Giordano,…

  Source: Cancer cell. 2004 Feb

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• Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems.

  For development of a new ligand-directed pharmacology, it is critical to measure delivery of targeted drug ligands via molecular imaging or diagnostic…

  Authors: Michael G Ozawa, Amado J Zurita, Emmanuel Dias-Neto, Diana N Nunes, Richard L Sidman, Juri G Gelovani, Wadih Arap, Renata Pasqualini

  Source: Trends in cardiovascular medicine. 2008 May

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• Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.

  A collection of 60 cell lines derived from human tumors (NCI-60) has been widely explored as a tool for anticancer drug discovery. Here, we profiled t…

  Authors: Mikhail G Kolonin, Laura Bover, Jessica Sun, Amado J Zurita, Kim-Anh Do, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J Giordano, Diana E Jaalouk, Michael G Ozawa,…

  Source: Cancer research. 2006 Jan 1

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• Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma.

  BACKGROUND: Previous studies of the TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model vasculature suggest that, as tumors develop, vessels…

  Authors: Michael G Ozawa, Virginia J Yao, Yvan H Chanthery, Patricia Troncoso, Akiyoshi Uemura, Amanda S Varner, Ian M Kasman, Renata Pasqualini, Wadih Arap, Donald M McDonald

  Source: Cancer. 2005 Nov 15

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• Ligand-directed cancer gene therapy to angiogenic vasculature.

  Gene therapy strategies in cancer have remained an active area of preclinical and clinical research. One of the current limitations to successful tria…

  Authors: Wouter H P Driessen, Michael G Ozawa, Wadih Arap, Renata Pasqualini

  Source: Advances in genetics. 2009

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• Techniques to decipher molecular diversity by phage display.

  Combinatorial phage display technology may be applied to decipher the molecular diversity of peptide binding specificity to isolated proteins, purifie…

  Authors: Dawn R Christianson, Michael G Ozawa, Renata Pasqualini, Wadih Arap

  Source: Methods in molecular biology (Clifton, N.J.). 2007

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