1 to 10 of 13 literature results

• Prediction of individual genetic risk of complex disease.

  Most common diseases are caused by multiple genetic and environmental factors. In the last 2 years, genome-wide association studies (GWAS) have identi…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Current opinion in genetics & development. 2008 Jun

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• Prediction of individual genetic risk to disease from genome-wide association studies.

  Empirical studies suggest that the effect sizes of individual causal risk alleles underlying complex genetic diseases are small, with most genotype re…

  Authors: Naomi R Wray, Michael E Goddard, Peter M Visscher

  Source: Genome research. 2007 Oct

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• Accuracy of genomic selection using stochastic search variable selection in Australian Holstein Friesian dairy cattle.

  Genomic selection describes a selection strategy based on genomic breeding values predicted from dense single nucleotide polymorphism (SNP) data. Mult…

  Authors: Klara L Verbyla, Ben J Hayes, Philip J Bowman, Michael E Goddard

  Source: Genetical research. 2009 Oct

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• A note on permutation tests for genetic association analysis of quantitative traits when variances are heterogeneous.

  The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage or association analysis in pedigrees and subsequent…

  Authors: Danielle Posthuma, Dirk-Jan de Koning, Conor Dolan, Michael E Goddard, Peter M Visscher

  Source: Genetic epidemiology. 2009 Dec

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• Multi-locus models of genetic risk of disease.

  ABSTRACT: BACKGROUND: Evidence for genetic contribution to complex diseases is described by recurrence risks to relatives of diseased individuals. Gen…

  Authors: Naomi R Wray, Michael E Goddard

  Source: Genome medicine. 2010 Feb 2

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• Mapping genes for complex traits in domestic animals and their use in breeding programmes.

  Genome-wide panels of SNPs have recently been used in domestic animal species to map and identify genes for many traits and to select genetically desi…

  Authors: Michael E Goddard, Ben J Hayes

  Source: Nature reviews. Genetics. 2009 Jun

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• The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling.

  Genome-wide association studies in human populations have facilitated the creation of genomic profiles which combine the effects of many associated ge…

  Authors: Naomi R Wray, Jian Yang, Michael E Goddard, Peter M Visscher

  Source: PLoS genetics. 2010 Feb

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• Data and theory point to mainly additive genetic variance for complex traits.

  The relative proportion of additive and non-additive variation for complex traits is important in evolutionary biology, medicine, and agriculture. We …

  Authors: William G Hill, Michael E Goddard, Peter M Visscher

  Source: PLoS genetics. 2008 Feb

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• Predicting unobserved phenotypes for complex traits from whole-genome SNP data.

  Genome-wide association studies (GWAS) for quantitative traits and disease in humans and other species have shown that there are many loci that contri…

  Authors: Sang Hong Lee, Julius H J van der Werf, Ben J Hayes, Michael E Goddard, Peter M Visscher

  Source: PLoS genetics. 2008 Oct

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• Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice.

  Ventilator-induced lung injury plays a crucial role in the outcome of patients with acute lung injury. Previous studies have shown a role for the cyto…

  Authors: Michael R Wilson, Michael E Goddard, Kieran P O'Dea, Sharmila Choudhury, Masao Takata

  Source: American journal of physiology. Lung cellular and molecular physiology. 2007 Jul

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